HitPredict

Interactor 1: EFNA2 (O43921)
Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L)
Gene: EFNA2

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.761

The method score is based on:

Property Details
Experiments 19836338
Identification Methods x-ray crystallography, pull down, molecular sieving, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ephrin~Ephrin_lbd
Common GO terms GO:0005886 - plasma membrane
GO:0007411 - axon guidance
GO:0031594 - neuromuscular junction
GO:0043204 - perikaryon
GO:0046875 - ephrin receptor binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 213
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025