HitPredict

Interactor 1: HIP1 (O00291)
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)
Gene: HIP1

Interactor 2: HIP1R (O75146)
Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)
Gene: HIP1R

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 28514442, 33961781, 11889126, 35271311, 36652389
Identification Methods affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANTH~ANTH, I_LWEQ~I_LWEQ
Common GO terms GO:0005829 - cytosol
GO:0006897 - endocytosis
GO:0007015 - actin filament organization
GO:0030100 - regulation of endocytosis
GO:0030136 - clathrin-coated vesicle
and 18 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1037
Hs

1 1068
+ Sp
+ Sc
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025