HitPredict

Interactor 1: GNB5 (O14775)
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
Gene: GNB5

Interactor 2: GBG7 (O60262)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene: GNG7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	8636150
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 395 Hs			1 68
+	Hs
		154670 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59
+	Hs
		154672 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87
+	Hs
		154666 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG4_HUMAN (2-68): 1.18e-24: 88.5: 60.29
+	Mm
		837708 GNB5_MOUSE (1-395): 6.78e-115: 342: 99.24		GBG4_MOUSE (2-68): 3.66e-24: 87.4: 61.77
+	Hs
		154673 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG5_HUMAN (1-68): 3.62e-24: 87: 51.47
+	Hs
		154700 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG8_HUMAN (2-68): 1.11e-23: 85.8: 52.94
+	Hs
		154698 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG13_HUMAN (7-68): 1.03e-20: 78.5: 30.65
+	Dm
		669788 GBB2_DROME (51-394): 1.66e-106: 319: 35.17		GBGE_DROME (9-68): 4.81e-19: 74.3: 30.00
+	Hs
		229235 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG7_HUMAN (1-68): 1.22e-28: 98.6: 100.00
+	Hs
		560893 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG12_HUMAN (2-68): 1.99e-26: 93.2: 77.61
+	Hs
		560868 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59
+	Hs
		560872 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87
+	Hs
		560865 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG10_HUMAN (1-68): 4.65e-25: 89.3: 52.94
+	Hs
		560864 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG4_HUMAN (2-68): 1.18e-24: 88.5: 60.29
+	Hs
		560873 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG5_HUMAN (1-68): 3.62e-24: 87: 51.47
+	Hs
		560895 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG8_HUMAN (2-68): 1.11e-23: 85.8: 52.94
+	Hs
		560892 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG13_HUMAN (7-68): 1.03e-20: 78.5: 30.65
+	Hs
		150112 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBGT2_HUMAN (10-67): 1.18e-18: 73.1: 44.83
+	Hs
		560869 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG11_HUMAN (9-67): 1.49e-18: 73.1: 40.68
+	Hs
		560871 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG1_HUMAN (9-67): 1.87e-18: 72.7: 38.33