HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 245
+	Hs
		440015 LCK_HUMAN (34-219): 1.82e-43: 154: 15.77		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		439959 LCK_HUMAN (34-219): 1.82e-43: 154: 15.77		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		440020 LCK_HUMAN (34-219): 1.82e-43: 154: 15.77		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		834166 CSK_HUMAN (3-220): 4.07e-38: 139: 12.45		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		156007 SOCS6_HUMAN (15-220): 6.8e-40: 145: 22.64		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		834168 CSK_HUMAN (3-220): 4.07e-38: 139: 12.45		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		729657 CSK_HUMAN (3-220): 4.07e-38: 139: 12.45		1433B_HUMAN (1-242): 5.04e-139: 391: 81.82
+	Mm
		148475 P85B_MOUSE (37-161): 3.14e-19: 87.5: 21.60		1433E_MOUSE (2-243): 1.32e-144: 406: 63.53
+	Hs
		136358 P85B_HUMAN (37-147): 7.14e-19: 86.4: 22.52		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		699680 P85A_HUMAN (35-153): 6.62e-18: 83.7: 18.49		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		136295 P85B_HUMAN (37-147): 7.14e-19: 86.4: 22.52		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		136364 P85B_HUMAN (37-147): 7.14e-19: 86.4: 22.52		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		699688 P85A_HUMAN (35-153): 6.62e-18: 83.7: 18.49		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		136307 P85B_HUMAN (37-147): 7.14e-19: 86.4: 22.52		1433B_HUMAN (1-242): 5.04e-139: 391: 81.82
+	Hs
		439970 LCK_HUMAN (34-219): 1.82e-43: 154: 15.77		1433S_HUMAN (1-236): 9.9e-108: 312: 71.85
+	Hs
		156033 SOCS6_HUMAN (15-220): 6.8e-40: 145: 22.64		1433F_HUMAN (2-242): 7.19e-106: 307: 71.43
+	Hs
		156022 SOCS6_HUMAN (15-220): 6.8e-40: 145: 22.64		1433G_HUMAN (1-242): 5.51e-105: 305: 70.33
+	Hs
		834164 CSK_HUMAN (3-220): 4.07e-38: 139: 12.45		1433G_HUMAN (1-242): 5.51e-105: 305: 70.33
+	Hs
		699678 P85A_HUMAN (35-153): 6.62e-18: 83.7: 18.49		1433G_HUMAN (1-242): 5.51e-105: 305: 70.33