HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	28883622
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 245
+	Hs
		156033 SOCS6_HUMAN (1-535): 0: 714: 100.00		1433F_HUMAN (2-242): 7.19e-106: 307: 71.43
+	Hs
		156022 SOCS6_HUMAN (1-535): 0: 714: 100.00		1433G_HUMAN (1-242): 5.51e-105: 305: 70.33
+	Hs
		440015 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		439959 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		440020 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		155913 SOCS3_HUMAN (372-533): 7.67e-38: 140: 26.56		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		439970 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		1433S_HUMAN (1-236): 9.9e-108: 312: 71.85
+	Hs
		136358 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Mm
		148475 P85B_MOUSE (380-491): 1.96e-14: 78.2: 27.68		1433E_MOUSE (2-243): 1.32e-144: 406: 63.53
+	Hs
		699680 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		1433E_HUMAN (2-243): 1.32e-144: 406: 63.53
+	Hs
		136295 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		1433T_HUMAN (1-245): 9.51e-142: 398: 100.00
+	Hs
		136364 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		699688 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59
+	Hs
		136307 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		1433B_HUMAN (1-242): 5.04e-139: 391: 81.82
+	Dm
		1019846 GRAP_DROME (371-461): 5.3e-12: 67: 26.88		1433E_DROME (2-242): 6.8e-143: 401: 65.02
+	Dm
		709529 GRAP_DROME (371-461): 5.3e-12: 67: 26.88		1433Z_DROME (1-245): 3.69e-141: 397: 77.14
+	Hs
		699678 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		1433G_HUMAN (1-242): 5.51e-105: 305: 70.33