HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	26186194, 28514442, 28330616, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 330
+	Hs
		155999 RPC1_HUMAN (1-1390): 0: 1782: 100.00		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Dm
		66189 A8JUY3_DROME (1-1384): 0: 1598: 57.06		PP12_DROME (7-304): 0: 553: 93.29
+	Hs
		624843 RPB1_HUMAN (2-1382): 0: 1534: 32.10		PP1A_HUMAN (1-330): 0: 614: 100.00
+	Hs
		624794 RPB1_HUMAN (2-1382): 0: 1534: 32.10		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Sp
		532281 RPB1_SCHPO (1-1372): 0: 1475: 32.95		PP11_SCHPO (6-329): 0: 557: 82.41
+	Hs
		624857 RPB1_HUMAN (2-1382): 0: 1534: 32.10		PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30
+	Sc
		375327 RPB1_YEAST (1-1381): 0: 1438: 31.80		PP12_YEAST (3-307): 0: 551: 84.26
+	Sc
		501342 RPA1_YEAST (7-146): 6.55e-36: 151: 22.86		PP12_YEAST (3-307): 0: 551: 84.26