HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: Q9UQC1 (Q9UQC1)
Heat shock protein 72
Gene: HSP70-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 756 Hs			1 151
+	Hs
		158411 IKKB_HUMAN (1-756): 0: 662: 100.00		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		158382 IKKB_HUMAN (1-756): 0: 662: 100.00		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		167636 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		871752 M3K5_HUMAN (14-657): 9.04e-137: 439: 20.00		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Hs
		871773 SIK2_HUMAN (6-753): 1.73e-132: 417: 17.45		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Hs
		1050214 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		Q53FC7_HUMAN (1-150): 1.89e-77: 243: 84.67
+	Hs
		1050300 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		504064 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		503460 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Sc
		419765 SNF1_YEAST (12-373): 3.79e-106: 339: 25.60		HSP73_YEAST (2-150): 8.28e-77: 241: 80.54
+	Sc
		419774 SNF1_YEAST (12-373): 3.79e-106: 339: 25.60		HSP71_YEAST (1-150): 2.5e-75: 237: 78.67
+	Hs
		1355361 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		504911 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Dm
		505090 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP7D_DROME (1-150): 2.33e-78: 245: 84.67
+	Dm
		669799 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP7A_DROME (1-150): 5.24e-77: 242: 82.67
+	Dm
		1213523 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP72_DROME (1-150): 1.49e-76: 240: 83.44
+	Dm
		365410 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP71_DROME (1-150): 1.8e-76: 240: 83.44
+	Dm
		1365056 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP74_DROME (1-150): 4.58e-76: 239: 82.78
+	Dm
		332639 IKKB_DROME (10-354): 5.1e-94: 311: 33.52		HSP68_DROME (1-150): 1.65e-75: 238: 81.46
+	Hs
		503439 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33