Protein: ERLN1
Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)

Gene: ERLN1, ERLIN1
Organism: Homo sapiens
Interactions: 227
UniProt ID: O75477

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008203 - cholesterol metabolic process
GO:0015485 - cholesterol binding
GO:0031625 - ubiquitin protein ligase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

266081

ERLN2
Erlin-2

9

5

Small-scale

0.975

High

266109

STOM
Stomatin

1

4

High-throughput

0.691

High

266212

AGR3
Anterior gradient protein 3

3

1

High-throughput

0.675

High

266229

RN170
E3 ubiquitin-protein ligase RNF170

3

3

High-throughput

0.667

High

266273

AMFR
E3 ubiquitin-protein ligase AMFR

3

5

Small-scale

0.662

High

266226

RN185
E3 ubiquitin-protein ligase RNF185

3

11

Small-scale

0.656

High

266186

FA2H
Fatty acid 2-hydroxylase

3

1

High-throughput

0.654

High

266112

CALX
Calnexin

3

2

High-throughput

0.650

High

266228

SC22A
Vesicle-trafficking protein SEC22a

3

0

High-throughput

0.646

High

266137

RHOA
Transforming protein RhoA

3

4

High-throughput

0.633

High

266184

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

2

3

High-throughput

0.628

High

266267

VAPA
Vesicle-associated membrane protein-associated protein A

2

3

High-throughput

0.628

High

266188

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

9

Small-scale

0.621

High

201732

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

2

1

Small-scale

0.611

High

266098

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.611

High

266238

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

2

3

Small-scale

0.611

High

266134

TERA
Transitional endoplasmic reticulum ATPase

2

0

Small-scale

0.585

High

266086

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.584

High

266152

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

2

4

Small-scale

0.584

High

266256

FBX6
F-box only protein 6

2

1

High-throughput

0.584

High

266164

SC23A
Protein transport protein Sec23A

2

0

High-throughput

0.580

High

266128

DUS3
Dual specificity protein phosphatase 3

2

3

High-throughput

0.574

High

266088

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

266176

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.571

High

266202

EMC1
ER membrane protein complex subunit 1

2

1

High-throughput

0.571

High

266236

ESYT1
Extended synaptotagmin-1

2

2

High-throughput

0.571

High

266115

PHB1
Prohibitin 1

1

4

High-throughput

0.553

High

266199

TM199
Transmembrane protein 199

1

0

High-throughput

0.549

High

266084

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

3

High-throughput

0.536

High

266106

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.536

High

266117

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

266118

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.536

High

266121

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.536

High

266133

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

266203

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.536

High

266222

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

266225

FAF2
FAS-associated factor 2

1

2

High-throughput

0.536

High

266241

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.536

High

266247

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

266277

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

266255

ANLN
Anillin

2

1

High-throughput

0.533

High

240664

USO1
General vesicular transport factor p115

1

1

High-throughput

0.515

High

70465

B2RDE6
cDNA, FLJ96578, highly similar to Homo sapiens fatty acid hydroxylase

1

1

High-throughput

0.515

High

149498

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

266168

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

266252

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.513

High

266107

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.500

High

266239

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.493

High

62188

ARRD5
Arrestin domain-containing protein 5

1

1

High-throughput

0.489

High

266108

ADA1D
Alpha-1D adrenergic receptor

1

2

Small-scale

0.489

High

266127

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.489

High

266160

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

266167

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.489

High

266177

CSCL2
CSC1-like protein 2

1

1

High-throughput

0.489

High

266185

COX15
Heme A synthase COX15

1

1

High-throughput

0.489

High

266268

MYEF2
Myelin expression factor 2

1

1

High-throughput

0.489

High

181019

INSI1
Insulin-induced gene 1 protein

1

1

Small-scale

0.479

High

226060

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

266082

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

266090

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

266092

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

266095

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

266097

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

266099

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.479

High

266101

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

266102

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

266135

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.479

High

266141

RAC1
Ras-related C3 botulinum toxin substrate 1

1

3

High-throughput

0.479

High

266146

TAP2
Antigen peptide transporter 2

1

1

Small-scale

0.479

High

266150

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

266154

CUL7
Cullin-7

1

1

High-throughput

0.479

High

266172

MBRL
Membralin

1

1

Small-scale

0.479

High

266174

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

266181

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

266198

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.479

High

266205

RN149
E3 ubiquitin-protein ligase RNF149

1

9

High-throughput

0.479

High

266213

RN139
E3 ubiquitin-protein ligase RNF139

1

7

Small-scale

0.479

High

266218

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

3

High-throughput

0.479

High

266223

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

266227

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

266233

RNF5
E3 ubiquitin-protein ligase RNF5

1

9

High-throughput

0.479

High

266243

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

3

Small-scale

0.479

High

266278

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

266279

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

266272

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.470

High

201143

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

266114

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

266119

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

266151

ARHG7
Rho guanine nucleotide exchange factor 7

1

0

High-throughput

0.458

High

266175

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

266217

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

48201

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.445

High

99759

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

258883

RTN2
Reticulon-2

1

3

High-throughput

0.445

High

266083

RTN3
Reticulon-3

1

3

High-throughput

0.445

High

266093

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

266096

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

266111

CALR
Calreticulin

1

2

High-throughput

0.445

High

266126

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

266162

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

266173

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

266194

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

266204

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.445

High

266206

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

266209

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

266216

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

266235

ERP44
Endoplasmic reticulum resident protein 44

1

2

High-throughput

0.445

High

266249

TMX1
Thioredoxin-related transmembrane protein 1

1

3

High-throughput

0.445

High

266254

RTN4
Reticulon-4

1

3

High-throughput

0.445

High

266262

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

1

Small-scale

0.445

High

266269

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

266275

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

266276

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

266281

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

172946

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

204827

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

266079

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

266091

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.437

High

266110

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

266116

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

266120

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

266131

RND2
Rho-related GTP-binding protein RhoN

1

4

High-throughput

0.437

High

266139

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.437

High

266142

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

266159

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

266165

RHOH
Rho-related GTP-binding protein RhoH

1

5

High-throughput

0.437

High

266170

DUS7
Dual specificity protein phosphatase 7

1

3

High-throughput

0.437

High

266178

FTM
Protein fantom

1

3

High-throughput

0.437

High

266182

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

266189

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.437

High

266191

MILK2
MICAL-like protein 2

1

1

High-throughput

0.437

High

266192

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

266220

KISSR
KiSS-1 receptor

1

3

Small-scale

0.437

High

266240

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

266250

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

266259

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

266263

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

266266

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.437

High

50064

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

58023

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

199247

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

202794

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

266085

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

266094

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

266100

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

266104

VINC
Vinculin

1

0

High-throughput

0.426

High

266105

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

266122

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

266129

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

266130

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

266132

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

266138

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

266140

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

266143

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

266145

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.426

High

266148

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

266155

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

266157

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

266158

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

266161

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

266163

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

266166

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

266180

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

266200

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

266207

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

266210

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

266215

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

266221

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

266224

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

266244

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

266248

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

266258

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

266265

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

99526

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

266080

MICA2
[F-actin]-monooxygenase MICAL2

1

1

High-throughput

0.407

High

266136

RAB8A
Ras-related protein Rab-8A

1

1

Small-scale

0.407

High

266179

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.407

High

266201

CD177
CD177 antigen

1

1

Small-scale

0.407

High

266230

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.407

High

266231

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.407

High

266251

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.407

High

266274

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.407

High

266187

CF120
UPF0669 protein C6orf120

2

0

High-throughput

0.328

High

266147

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

0

High-throughput

0.316

High

266195

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.316

High

266214

DEP1B
DEP domain-containing protein 1B

2

0

High-throughput

0.298

High

266219

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.298

High

206990

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

266087

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

266169

DREB
Drebrin

1

0

High-throughput

0.279

Low

266211

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

266257

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

266282

RPKL1
Ribosomal protein S6 kinase-like 1

1

0

High-throughput

0.279

Low

266270

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.269

Low

148211

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

209531

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

266089

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

266103

EGR1
Early growth response protein 1

1

0

Small-scale

0.249

Low

266113

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

Small-scale

0.249

Low

266124

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

266149

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.249

Low

266156

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

266171

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

266190

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low

266193

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

266196

FBXW8
F-box/WD repeat-containing protein 8

1

0

High-throughput

0.249

Low

266197

NIN
Ninein

1

0

High-throughput

0.249

Low

266245

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

266271

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

200956

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

266078

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.232

Low

266123

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.232

Low

266125

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

266144

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.232

Low

266153

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.232

Low

266183

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.232

Low

266208

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

266232

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

266234

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

266237

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

266242

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.232

Low

266246

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

266253

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

266260

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

266261

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

266264

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low

266280

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024