HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26508657, 14602072
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031623 - receptor internalization GO:0031901 - early endosome membrane GO:0044389 - ubiquitin-like protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 903
+	Hs
		125001 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		277114 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		160160 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1294876 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1270607 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125035 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		159925 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		125533 TM1L2_HUMAN (5-448): 6.41e-50: 185: 17.17		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125613 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		241153 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808171 TM1L2_HUMAN (5-448): 6.41e-50: 185: 17.17		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808298 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		241199 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1173029 TM1L2_HUMAN (5-448): 6.41e-50: 185: 17.17		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Sc
		765278 VPS27_YEAST (3-650): 4.65e-44: 170: 18.35		RSP5_YEAST (16-440): 9.75e-40: 160: 19.07
+	Hs
		1336102 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71