HitPredict

Interactor 1: CLGN (O14967)
Calmegin
Gene: CLGN

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 610 Hs			1 1114
+	Hs
		434139 CALX_HUMAN (29-610): 0: 729: 56.85		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		161008 CLGN_HUMAN (1-610): 0: 804: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		160994 CLGN_HUMAN (1-610): 0: 804: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		160995 CLGN_HUMAN (1-610): 0: 804: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		601462 CALX_HUMAN (29-610): 0: 729: 56.85		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		507869 CALX_HUMAN (29-610): 0: 729: 56.85		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		337977 CALX_HUMAN (29-610): 0: 729: 56.85		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383628 CALX_HUMAN (29-610): 0: 729: 56.85		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		384315 CALX_HUMAN (29-610): 0: 729: 56.85		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		161071 CLGN_HUMAN (1-610): 0: 804: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		607885 CALX_HUMAN (29-610): 0: 729: 56.85		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		654370 CALX_HUMAN (29-610): 0: 729: 56.85		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		161030 CLGN_HUMAN (1-610): 0: 804: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		161031 CLGN_HUMAN (1-610): 0: 804: 100.00		FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00
+	Hs
		654121 CALX_HUMAN (29-610): 0: 729: 56.85		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		654124 CALX_HUMAN (29-610): 0: 729: 56.85		FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00
+	At
		83441 CALX2_ARATH (59-539): 1.44e-137: 413: 38.45		Y1755_ARATH (249-1039): 2.56e-178: 546: 14.35
+	At
		248528 CALX2_ARATH (59-539): 1.44e-137: 413: 38.45		SIRK_ARATH (246-1009): 1.27e-151: 476: 12.23
+	Hs
		337975 CALR_HUMAN (60-456): 2.91e-129: 387: 36.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		384313 CALR_HUMAN (60-456): 2.91e-129: 387: 36.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69