Protein: ADA21
Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21) (EC 3.4.24.-)

Gene: ADA21, ADAM21
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9UKJ8

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0007338 - single fertilization
GO:0008237 - metallopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1413592

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

2

1

High-throughput

0.811

High

1417802

LRRC3
Leucine-rich repeat-containing protein 3

2

3

High-throughput

0.811

High

1459914

EGFL7
Epidermal growth factor-like protein 7

2

12

High-throughput

0.726

High

273793

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

14

High-throughput

0.691

High

480460

CD48
CD48 antigen

1

4

High-throughput

0.691

High

1363162

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.691

High

1430744

SIRPD
Signal-regulatory protein delta

1

4

High-throughput

0.691

High

1460478

BTNL2
Butyrophilin-like protein 2

1

7

High-throughput

0.691

High

269712

PLXA2
Plexin-A2

2

4

High-throughput

0.628

High

612127

ITB5
Integrin beta-5

2

12

High-throughput

0.628

High

1258467

CHSS3
Chondroitin sulfate synthase 3

2

5

High-throughput

0.628

High

1278335

LRP10
Low-density lipoprotein receptor-related protein 10

2

15

High-throughput

0.628

High

568013

PRG2
Bone marrow proteoglycan

1

13

High-throughput

0.618

High

1292561

AMGO1
Amphoterin-induced protein 1

1

4

High-throughput

0.618

High

762171

CNR2
Cannabinoid receptor 2

2

0

High-throughput

0.580

High

351747

SG1D1
Secretoglobin family 1D member 1

2

1

High-throughput

0.574

High

699244

CALX
Calnexin

2

17

High-throughput

0.574

High

889938

VEGFB
Vascular endothelial growth factor B

2

3

High-throughput

0.574

High

977858

ACTA
Actin, aortic smooth muscle

2

2

High-throughput

0.574

High

1248690

LCLT1
Lysocardiolipin acyltransferase 1

2

3

High-throughput

0.574

High

1293694

DYR2
Dihydrofolate reductase 2, mitochondrial

2

3

High-throughput

0.574

High

1461113

CCPG1
Cell cycle progression protein 1

2

1

High-throughput

0.574

High

226909

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

1

High-throughput

0.553

High

380182

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

12

High-throughput

0.552

High

64397

CDHR4
Cadherin-related family member 4

1

4

High-throughput

0.536

High

175450

PLXB2
Plexin-B2

1

4

High-throughput

0.536

High

283724

GPC4
Glypican-4

1

1

High-throughput

0.536

High

455668

KLK3
Prostate-specific antigen

1

20

High-throughput

0.536

High

469846

CATG
Cathepsin G

1

17

High-throughput

0.536

High

535661

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.536

High

561395

TDGF1
Protein Cripto

1

5

High-throughput

0.536

High

568098

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

12

High-throughput

0.536

High

607430

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

12

High-throughput

0.536

High

719757

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

12

High-throughput

0.536

High

984328

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

1234007

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

2

High-throughput

0.536

High

1324285

LYPD1
Ly6/PLAUR domain-containing protein 1

1

4

High-throughput

0.536

High

1432128

KLK15
Kallikrein-15

1

13

High-throughput

0.536

High

1438290

DEFM
Peptide deformylase, mitochondrial

1

1

High-throughput

0.536

High

387758

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

High-throughput

0.515

High

251129

B4GT3
Beta-1,4-galactosyltransferase 3

1

0

High-throughput

0.513

High

1333791

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

1404311

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.513

High

164780

GDF8
Growth/differentiation factor 8

1

4

High-throughput

0.489

High

342694

LY86
Lymphocyte antigen 86

1

3

High-throughput

0.489

High

416657

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

548149

PSPC
Surfactant protein C

1

4

High-throughput

0.489

High

933243

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.489

High

1213732

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

16

High-throughput

0.489

High

1245943

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

1248810

LYZL1
Lysozyme-like protein 1

1

4

High-throughput

0.489

High

1292152

ANR46
Ankyrin repeat domain-containing protein 46

1

5

High-throughput

0.489

High

1348359

GOGA5
Golgin subfamily A member 5

1

3

High-throughput

0.489

High

1360166

PATE1
Prostate and testis expressed protein 1

1

4

High-throughput

0.489

High

1369085

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1433669

CST9L
Cystatin-9-like

1

5

High-throughput

0.489

High

1450255

TM39A
Transmembrane protein 39A

1

2

High-throughput

0.489

High

1461114

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.489

High

936224

MANF
Mesencephalic astrocyte-derived neurotrophic factor

2

0

High-throughput

0.328

High

1459940

PCS1N
ProSAAS

2

0

High-throughput

0.328

High

337199

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

1356814

NEUFC
Neuferricin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025