HitPredict

Interactor 1: HNRDL (O14979)
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)
Gene: HNRNPDL

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003690 - double-stranded DNA binding GO:0003697 - single-stranded DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus and 1 others more... GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 765
+	Hs
		453106 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508407 ROA3_HUMAN (140-317): 8.69e-82: 257: 37.50		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508336 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508516 HNRPD_HUMAN (111-420): 3.55e-62: 206: 56.45		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508679 ROAA_HUMAN (19-233): 6.29e-24: 103: 18.81		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Sc
		376565 PABP_YEAST (115-327): 6.49e-38: 146: 16.59		TOP1_YEAST (600-765): 7.36e-26: 115: 34.88