Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.939

The method score is based on:

Property Details
Experiments 15070904, 11046132, 11533036, 31839598, 19446522, 34189428
Identification Methods pull down, far western blotting, cross-linking study, nuclear magnetic resonance, blue native page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EBP50_C~PDZ, PDZ~PDZ
Common GO terms GO:0001726 - ruffle
GO:0002009 - morphogenesis of an epithelium
GO:0003096 - renal sodium ion transport
GO:0005102 - signaling receptor binding
GO:0005737 - cytoplasm
and 65 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 358
Hs

1 358
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+ Mm
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+ Hs
+ Dm
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+ Rn
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+ Mm
+ Mm
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+ Rn
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025