Protein: NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)

Gene: NHRF3, PDZK1
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q5T2W1

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005124 - scavenger receptor binding
GO:0005886 - plasma membrane
GO:0005903 - brush border
GO:0016324 - apical plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1212231

OTUL
Ubiquitin thioesterase otulin

2

4

High-throughput

0.705

High

162839

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

19

Small-scale

0.680

High

563883

CFTR
Cystic fibrosis transmembrane conductance regulator

3

16

Small-scale

0.675

High

1212235

ACE2
Angiotensin-converting enzyme 2

3

3

Small-scale

0.674

High

1094842

PDZ1I
PDZK1-interacting protein 1

3

3

Small-scale

0.663

High

540032

BCR
Breakpoint cluster region protein

3

20

Small-scale

0.662

High

190614

MRP4
ATP-binding cassette sub-family C member 4

3

9

Small-scale

0.660

High

1212229

SCRB1
Scavenger receptor class B member 1

3

1

Small-scale

0.656

High

1201815

SDK2
Protein sidekick-2

1

20

High-throughput

0.647

High

1150434

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

17

Small-scale

0.621

High

375592

RASK
GTPase KRas

1

20

High-throughput

0.618

High

303239

S22A5
Organic cation/carnitine transporter 2

2

4

High-throughput

0.611

High

727530

SC6A6
Sodium- and chloride-dependent taurine transporter

2

20

High-throughput

0.611

High

844795

EAA1
Excitatory amino acid transporter 1

2

8

High-throughput

0.611

High

1130008

KCTD2
BTB/POZ domain-containing protein KCTD2

2

20

High-throughput

0.611

High

1207947

COL12
Collectin-12

2

2

High-throughput

0.611

High

1212223

RHG17
Rho GTPase-activating protein 17

2

20

High-throughput

0.611

High

1212237

S19A3
Thiamine transporter 2

2

1

High-throughput

0.611

High

1212242

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

2

3

High-throughput

0.611

High

1212245

KCTD5
BTB/POZ domain-containing protein KCTD5

2

20

High-throughput

0.611

High

1212247

SC5A6
Sodium-dependent multivitamin transporter

2

1

High-throughput

0.611

High

1212249

KCTD3
BTB/POZ domain-containing protein KCTD3

2

20

High-throughput

0.611

High

1212251

S4A7
Sodium bicarbonate cotransporter 3

2

10

High-throughput

0.611

High

1212230

MRP2
ATP-binding cassette sub-family C member 2

2

9

Small-scale

0.594

High

907714

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

Small-scale

0.578

High

570447

GFAP
Glial fibrillary acidic protein

2

13

High-throughput

0.573

High

176405

ZBTB5
Zinc finger and BTB domain-containing protein 5

2

12

High-throughput

0.558

High

284579

ECI2
Enoyl-CoA delta isomerase 2

2

2

High-throughput

0.558

High

321914

FRYL
Protein furry homolog-like

2

3

High-throughput

0.558

High

354230

ZBED1
E3 SUMO-protein ligase ZBED1

2

4

High-throughput

0.558

High

625435

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.558

High

1212224

KLH17
Kelch-like protein 17

2

10

High-throughput

0.558

High

1212225

KLH24
Kelch-like protein 24

2

9

High-throughput

0.558

High

1212226

SH2D5
SH2 domain-containing protein 5

2

1

High-throughput

0.558

High

1212227

KCD17
BTB/POZ domain-containing protein KCTD17

2

20

High-throughput

0.558

High

1212228

SHKB1
SH3KBP1-binding protein 1

2

20

High-throughput

0.558

High

1212233

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

2

1

High-throughput

0.558

High

1212244

ASND1
Asparagine synthetase domain-containing protein 1

2

3

High-throughput

0.558

High

1212250

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

4

High-throughput

0.558

High

845512

PI2R
Prostacyclin receptor

1

20

Small-scale

0.552

High

220599

AKA10
A-kinase anchor protein 10, mitochondrial

1

1

Small-scale

0.527

High

1055409

NPT2A
Sodium-dependent phosphate transport protein 2A

1

8

Small-scale

0.527

High

1212232

S22AC
Solute carrier family 22 member 12

1

3

Small-scale

0.527

High

1212239

S22A4
Solute carrier family 22 member 4

1

3

Small-scale

0.527

High

1212240

SLK
STE20-like serine/threonine-protein kinase

1

20

Small-scale

0.527

High

713102

NOS3
Nitric oxide synthase 3

1

6

High-throughput

0.515

High

770719

SSR5
Somatostatin receptor type 5

1

20

Small-scale

0.506

High

422284

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

669091

GUC2C
Guanylyl cyclase C

1

11

Small-scale

0.501

High

762203

CRFR1
Corticotropin-releasing factor receptor 1

1

20

Small-scale

0.501

High

1101507

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.501

High

1212234

S26A6
Solute carrier family 26 member 6

1

6

High-throughput

0.501

High

1212241

CLTR2
Cysteinyl leukotriene receptor 2

1

20

High-throughput

0.501

High

896248

PEX5
Peroxisomal targeting signal 1 receptor

1

6

High-throughput

0.494

High

320564

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

14

Small-scale

0.481

High

877676

SL9A3
Sodium/hydrogen exchanger 3

1

6

Small-scale

0.481

High

1133344

NPT1
Sodium-dependent phosphate transport protein 1

1

3

Small-scale

0.481

High

1212238

S13A1
Solute carrier family 13 member 1

1

2

Small-scale

0.481

High

396280

ESR1
Estrogen receptor

1

13

High-throughput

0.479

High

728285

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.479

High

622179

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.470

High

1158367

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

66031

S15A5
Solute carrier family 15 member 5

1

1

High-throughput

0.457

High

1212246

SPHK1
Sphingosine kinase 1

1

8

Small-scale

0.445

High

993607

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.439

High

948858

CD81
CD81 antigen

1

0

High-throughput

0.426

High

1148344

KS6A1
Ribosomal protein S6 kinase alpha-1

1

18

Small-scale

0.373

High

1212236

PUS3
tRNA pseudouridine(38/39) synthase

1

0

High-throughput

0.261

Low

1212248

PIGL
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

1

0

High-throughput

0.261

Low

1212243

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025