HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 1052
+	Mm
		757443 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		FAK1_MOUSE (1-1052): 0: 1135: 97.34
+	Mm
		813525 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		Q8C2G0_MOUSE (35-1043): 0: 857: 44.43
+	Hs
		187238 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		ABL1_HUMAN (245-1017): 3.03e-123: 406: 20.61
+	Hs
		362121 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		ABL1_HUMAN (245-1017): 3.03e-123: 406: 20.61
+	Mm
		813512 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		EPHA4_MOUSE (297-760): 2.01e-120: 395: 28.05
+	Hs
		400119 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		RAF1_HUMAN (106-714): 5.35e-121: 387: 16.90
+	Hs
		187295 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		EPHA2_HUMAN (373-774): 5.28e-116: 383: 31.46
+	Hs
		440363 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		FGFR2_HUMAN (344-723): 9.56e-116: 378: 28.40
+	Mm
		813518 SH21C_MOUSE (1-132): 1.88e-42: 138: 65.91		FYN_MOUSE (415-689): 2.25e-112: 360: 37.32
+	Hs
		164846 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		SRC_HUMAN (415-689): 1.15e-113: 363: 38.77
+	Hs
		440323 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		SRC_HUMAN (415-689): 1.15e-113: 363: 38.77
+	Hs
		440290 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		FYN_HUMAN (415-689): 1.13e-112: 361: 37.32
+	Hs
		440300 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		YES_HUMAN (415-689): 7.5e-112: 359: 37.68
+	Hs
		439898 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		LCK_HUMAN (412-691): 6.94e-111: 355: 37.37
+	Hs
		187287 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		EPHA1_HUMAN (428-680): 4.62e-63: 234: 45.88
+	Hs
		440362 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		EPHA1_HUMAN (428-680): 4.62e-63: 234: 45.88
+	Dm
		1466640 SRC42_DROME (3-131): 5.92e-37: 133: 26.52		SRC42_DROME (412-689): 3.29e-62: 223: 40.99
+	Hs
		164861 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		ERBB4_HUMAN (408-695): 1.2e-58: 222: 39.53
+	Hs
		187353 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		ERBB4_HUMAN (408-695): 1.2e-58: 222: 39.53
+	Dm
		1466642 Q9VGK8_DROME (3-129): 1.63e-35: 130: 26.77		SRC42_DROME (412-689): 3.29e-62: 223: 40.99