Protein: SH21B
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)

Gene: SH21B, SH2D1B
Organism: Homo sapiens
Interactions: 46
UniProt ID: O14796

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002366 - leukocyte activation involved in immune response
GO:0002717 - positive regulation of natural killer cell mediated immunity
GO:0005829 - cytosol
GO:0030674 - protein-macromolecule adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164852

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

164856

ACK1
Activated CDC42 kinase 1

2

20

High-throughput

0.783

High

164841

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

164860

STAT4
Signal transducer and activator of transcription 4

2

18

High-throughput

0.767

High

164854

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.743

High

164848

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

20

Small-scale

0.710

High

164849

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.710

High

164877

ROBO1
Roundabout homolog 1

1

8

High-throughput

0.691

High

164872

TRI54
Tripartite motif-containing protein 54

3

20

High-throughput

0.675

High

164846

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.665

High

164839

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

164861

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

164873

CD244
Natural killer cell receptor 2B4

2

20

Small-scale

0.624

High

164875

SLAF5
SLAM family member 5

3

20

Small-scale

0.624

High

164857

SLAF1
Signaling lymphocytic activation molecule

3

20

Small-scale

0.623

High

164843

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

164845

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.619

High

164869

SLAF6
SLAM family member 6

2

20

Small-scale

0.584

High

164850

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.579

High

164836

SH21A
SH2 domain-containing protein 1A

1

18

Small-scale

0.575

High

164867

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.575

High

164871

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

20

Small-scale

0.575

High

164876

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

1

20

Small-scale

0.575

High

164866

OLIG1
Oligodendrocyte transcription factor 1

2

4

High-throughput

0.573

High

164833

MAGB4
Melanoma-associated antigen B4

2

4

High-throughput

0.553

High

164838

AGR2
Anterior gradient protein 2 homolog

2

3

High-throughput

0.553

High

164865

IKBD
NF-kappa-B inhibitor delta

2

14

High-throughput

0.553

High

164855

PRDX1
Peroxiredoxin-1

1

3

High-throughput

0.541

High

164844

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

164859

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

164858

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

9

High-throughput

0.526

High

164835

ANM3
Protein arginine N-methyltransferase 3

1

4

High-throughput

0.515

High

164840

FOS
Protein c-Fos

1

6

High-throughput

0.515

High

164842

A4
Amyloid-beta precursor protein

1

15

High-throughput

0.501

High

164874

SLAF7
SLAM family member 7

1

20

Small-scale

0.501

High

159115

ABLM1
Actin-binding LIM protein 1

1

20

High-throughput

0.489

High

164853

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

11

High-throughput

0.489

High

164862

Q53HF2
Heat shock 70kDa protein 8 isoform 2 variant

1

20

High-throughput

0.477

High

164837

WFS1
Wolframin

1

1

High-throughput

0.470

High

164863

Q6FHY5
MEOX2 protein

1

17

High-throughput

0.470

High

164868

DDT4L
DNA damage-inducible transcript 4-like protein

1

4

High-throughput

0.470

High

164834

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

20

Small-scale

0.445

High

164847

PECA1
Platelet endothelial cell adhesion molecule

1

20

Small-scale

0.445

High

164851

MEOX2
Homeobox protein MOX-2

1

9

High-throughput

0.439

High

164864

NUTM1
NUT family member 1

1

2

High-throughput

0.439

High

164870

HTF4
Transcription factor 12

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025