HitPredict

Interactor 1: PER2 (O15055)
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
Gene: PER2

Interactor 2: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23555304
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032922 - circadian regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 518
+	Hs
		846423 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		RORG_HUMAN (1-518): 1.29e-153: 450: 100.00
+	Hs
		846420 BMAL2_HUMAN (51-596): 2.02e-117: 381: 19.67		RORG_HUMAN (1-518): 1.29e-153: 450: 100.00
+	Mm
		222697 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		NR1D1_MOUSE (1-488): 5.52e-107: 333: 29.69
+	Hs
		126112 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		RORG_HUMAN (1-518): 1.29e-153: 450: 100.00
+	Mm
		846435 HIF1A_MOUSE (83-819): 7.28e-106: 356: 12.26		RORG_MOUSE (1-518): 1.51e-142: 422: 88.61
+	Hs
		723182 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		RORA_HUMAN (6-516): 7.11e-126: 379: 47.95
+	Hs
		130327 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26
+	Hs
		265869 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41
+	Hs
		509955 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		VDR_HUMAN (11-509): 2.77e-74: 243: 18.04
+	Hs
		587195 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73
+	Hs
		488019 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		RARA_HUMAN (3-105): 1.29e-39: 151: 47.12
+	Dm
		429412 PER_DROME (191-1159): 2.63e-139: 457: 16.94		E75BB_DROME (257-490): 4.95e-13: 73.9: 26.00
+	Hs
		126103 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73
+	Hs
		740529 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39
+	Hs
		587173 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73
+	Hs
		126099 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		RARA_HUMAN (3-105): 1.29e-39: 151: 47.12
+	Hs
		975430 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		PPARD_HUMAN (29-133): 2.16e-41: 155: 47.17
+	Hs
		500487 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		THB_HUMAN (6-165): 2.41e-40: 153: 32.40
+	Hs
		487974 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		RARA_HUMAN (3-105): 1.29e-39: 151: 47.12
+	Hs
		490101 NCOA2_HUMAN (77-1254): 1e-98: 347: 13.39		COT1_HUMAN (29-110): 1.23e-26: 114: 60.98