HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: DCX (O43602)
Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)
Gene: DCX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DCX~DCX
Common GO terms	GO:0001764 - neuron migration GO:0007399 - nervous system development GO:0007417 - central nervous system development GO:0035556 - intracellular signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 740 Hs			1 365
+	Mm
		292341 DCLK1_MOUSE (1-740): 0: 883: 96.43		DCX_MOUSE (1-365): 1.73e-180: 506: 99.18
+	Hs
		166519 DCLK1_HUMAN (1-740): 0: 896: 100.00		DCLK1_HUMAN (2-347): 5.53e-146: 432: 72.41
+	Mm
		1337540 DCLK1_MOUSE (1-740): 0: 883: 96.43		DCLK1_MOUSE (2-347): 4.65e-148: 438: 72.41
+	Dr
		56441 A2A121_DANRE (3-738): 0: 765: 61.35		A2A121_DANRE (2-334): 3.37e-141: 421: 61.54
+	Hs
		208229 DCX_HUMAN (6-345): 2.97e-136: 407: 72.13		DCX_HUMAN (1-365): 0: 509: 100.00
+	Rn
		506735 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		DCLK2_RAT (2-349): 1.5e-140: 419: 64.88