HitPredict

Interactor 1: IFIT3 (O14879)
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
Gene: IFIT3

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21813773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0051607 - defense response to virus GO:0140374 - antiviral innate immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 540
+	Hs
		488182 IFIT1_HUMAN (1-444): 9.95e-100: 309: 43.13		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		185816 OGT1_HUMAN (91-479): 2.85e-52: 192: 14.50		HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36
+	Mm
		1274322 OGT1_MOUSE (91-479): 1.97e-52: 192: 14.50		HUWE1_MOUSE (108-539): 5.17e-18: 90.3: 13.89
+	Hs
		185700 OGT1_HUMAN (91-479): 2.85e-52: 192: 14.50		MDC1_HUMAN (79-450): 8.81e-11: 67.1: 13.06
+	Hs
		185866 OGT1_HUMAN (91-479): 2.85e-52: 192: 14.50		KMT2C_HUMAN (102-538): 1.41e-09: 63.3: 10.60
+	Hs
		194588 KDM6A_HUMAN (22-416): 1.59e-26: 116: 10.84		KMT2C_HUMAN (102-538): 1.41e-09: 63.3: 10.60
+	Hs
		158698 UTY_HUMAN (22-400): 3.18e-26: 114: 12.40		KMT2C_HUMAN (102-538): 1.41e-09: 63.3: 10.60
+	Hs
		718565 CDC27_HUMAN (124-483): 1.34e-14: 78.8: 11.51		MDC1_HUMAN (79-450): 8.81e-11: 67.1: 13.06