HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TRI27 (P14373)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Gene: TRIM27

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	16393995
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, in-gel kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045087 - innate immune response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 513
+	Hs
		158386 IKKB_HUMAN (1-743): 0: 583: 50.87		TRI27_HUMAN (1-513): 0: 523: 100.00
+	Hs
		158392 IKKB_HUMAN (1-743): 0: 583: 50.87		RO52_HUMAN (1-500): 2.33e-160: 465: 36.78
+	Hs
		167580 IKKA_HUMAN (1-745): 0: 588: 100.00		TRI22_HUMAN (1-494): 2.57e-131: 392: 29.12
+	Mm
		1143608 TBK1_MOUSE (15-726): 8e-127: 396: 18.68		TRI27_MOUSE (1-513): 0: 524: 98.83
+	Hs
		537119 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI27_HUMAN (1-513): 0: 523: 100.00
+	Hs
		536827 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRI27_HUMAN (1-513): 0: 523: 100.00
+	Hs
		585090 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		RO52_HUMAN (1-500): 2.33e-160: 465: 36.78
+	Hs
		584875 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		RO52_HUMAN (1-500): 2.33e-160: 465: 36.78
+	Hs
		1318703 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRIM7_HUMAN (11-481): 1.25e-132: 396: 38.01
+	Hs
		1050264 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRIM6_HUMAN (1-494): 5.87e-134: 398: 32.42
+	Hs
		1050263 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRIM7_HUMAN (11-481): 1.25e-132: 396: 38.01
+	Hs
		1354523 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI10_HUMAN (1-480): 7.29e-125: 375: 34.36
+	Mm
		250797 ULK1_MOUSE (7-221): 2.26e-30: 130: 34.50		TRI27_MOUSE (1-513): 0: 524: 98.83
+	Hs
		262230 ULK1_HUMAN (7-221): 7.48e-30: 129: 34.50		TRI27_HUMAN (1-513): 0: 523: 100.00
+	Hs
		262235 ULK1_HUMAN (7-221): 7.48e-30: 129: 34.50		RO52_HUMAN (1-500): 2.33e-160: 465: 36.78
+	Hs
		1290895 MARK1_HUMAN (13-221): 9.17e-25: 112: 34.11		TRI11_HUMAN (1-500): 9.03e-148: 433: 38.00
+	Hs
		183318 ULK1_HUMAN (7-221): 7.48e-30: 129: 34.50		MEFV_HUMAN (17-496): 5.93e-131: 400: 37.04
+	Hs
		1019379 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI26_HUMAN (385-482): 2.75e-09: 61.6: 40.40