HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22074159
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Hs			1 330
+	Hs
		167735 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23
+	Mm
		193087 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73
+	Hs
		167742 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08
+	Hs
		167747 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		CRK_HUMAN (46-330): 1.14e-34: 130: 18.87
+	Mm
		193088 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LCK_MOUSE (3-136): 1.79e-53: 184: 34.46
+	Hs
		167737 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00
+	Hs
		167751 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		167748 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		CRKL_HUMAN (248-330): 9.75e-12: 66.8: 22.62
+	Mm
		193090 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		FYN_MOUSE (222-329): 3.84e-22: 98.7: 30.00
+	Mm
		193089 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LYN_MOUSE (239-329): 3.12e-14: 75.2: 22.58
+	Hs
		411582 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LCK_HUMAN (3-136): 1.04e-53: 185: 34.46
+	Hs
		337335 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23
+	Hs
		411823 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LCK_HUMAN (3-136): 1.04e-53: 185: 34.46
+	Hs
		433560 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12
+	Hs
		522749 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93
+	Hs
		1186102 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		CD2AP_HUMAN (280-330): 4.65e-16: 81: 34.62
+	Hs
		433853 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		433948 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12
+	Hs
		297808 K0754_HUMAN (250-731): 8.54e-16: 84.6: 7.68		LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12