HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	24981860, 33961781, 35271311, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0005903 - brush border GO:0016460 - myosin II complex GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 172 Hs			1 151
+	Hs
		169044 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYL4_HUMAN (3-151): 2.19e-57: 179: 77.48
+	Hs
		169041 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYL1_HUMAN (3-150): 6.65e-56: 175: 74.32
+	Hs
		437565 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYL1_HUMAN (3-150): 6.65e-56: 175: 74.32
+	Hs
		169049 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYL6B_HUMAN (3-150): 1.49e-44: 146: 81.76
+	Hs
		573923 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYL6B_HUMAN (3-150): 1.49e-44: 146: 81.76
+	Mm
		483495 MLRV_MOUSE (9-166): 3.71e-54: 170: 55.98		MYL3_MOUSE (3-150): 8.58e-56: 175: 74.00
+	Hs
		573921 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYL6B_HUMAN (3-150): 1.49e-44: 146: 81.76
+	Hs
		666746 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYL6_HUMAN (1-151): 9.74e-44: 143: 100.00
+	Hs
		618674 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYL6_HUMAN (1-151): 9.74e-44: 143: 100.00
+	Ce
		624588 MLR1_CAEEL (24-170): 2.52e-39: 133: 49.32		MLE_CAEEL (12-151): 6.38e-36: 123: 46.43
+	Ce
		624592 MLR2_CAEEL (24-170): 1.92e-39: 133: 49.32		MLE_CAEEL (12-151): 6.38e-36: 123: 46.43
+	At
		947493 CALM6_ARATH (98-171): 6.78e-17: 74.9: 25.68		CALM7_ARATH (3-150): 1.9e-44: 144: 44.97
+	At
		515475 CDPK3_ARATH (103-172): 2.22e-14: 71.8: 22.86		CALM4_ARATH (3-150): 1.15e-44: 145: 44.30
+	At
		1043029 CDPK3_ARATH (103-172): 2.22e-14: 71.8: 22.86		CALM6_ARATH (3-150): 2.34e-44: 144: 44.30
+	At
		947502 CDPK3_ARATH (103-172): 2.22e-14: 71.8: 22.86		CALM7_ARATH (3-150): 1.9e-44: 144: 44.97
+	At
		1057375 CDPK1_ARATH (83-172): 4.09e-14: 71: 22.58		CDPK1_ARATH (73-146): 9.65e-10: 57.5: 21.33
+	At
		1183276 CDPKB_ARATH (103-172): 2.75e-13: 68.3: 27.14		CDPKB_ARATH (73-146): 2.06e-10: 59.4: 22.67
+	At
		1182290 CDPK4_ARATH (37-172): 1.33e-13: 69.5: 19.73		CDPK4_ARATH (15-146): 1.18e-09: 57.1: 16.43
+	Hs
		516311 CALL3_HUMAN (32-93): 7.09e-11: 59: 25.76		CALM1_HUMAN (5-77): 1.96e-12: 62.5: 28.77