Protein: ML12B
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)

Gene: ML12B, MYL12B
Organism: Homo sapiens
Interactions: 154
UniProt ID: O14950

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005903 - brush border

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

169064

MYH9
Myosin-9

8

19

High-throughput

0.963

High

169065

MYH10
Myosin-10

4

20

High-throughput

0.881

High

169126

MY18A
Unconventional myosin-XVIIIa

3

20

High-throughput

0.855

High

169069

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

16

High-throughput

0.776

High

169114

MYH14
Myosin-14

2

19

High-throughput

0.776

High

169131

MYO19
Unconventional myosin-XIX

2

20

High-throughput

0.776

High

169171

MYO5A
Unconventional myosin-Va

2

16

High-throughput

0.776

High

169053

ML12A
Myosin regulatory light chain 12A

2

16

High-throughput

0.737

High

169059

MYL9
Myosin regulatory light polypeptide 9

2

13

High-throughput

0.737

High

169066

MYH11
Myosin-11

2

20

Small-scale

0.737

High

69693

EFCB7
EF-hand calcium-binding domain-containing protein 7

1

17

High-throughput

0.691

High

143498

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.691

High

169088

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

20

High-throughput

0.691

High

169119

MYO3A
Myosin-IIIa

1

20

High-throughput

0.691

High

169124

MYO3B
Myosin-IIIb

1

20

High-throughput

0.691

High

169159

MYO6
Unconventional myosin-VI

1

20

High-throughput

0.691

High

169165

MYH15
Myosin-15

1

19

High-throughput

0.691

High

169075

MYL6
Myosin light polypeptide 6

4

19

High-throughput

0.691

High

169073

DAPK1
Death-associated protein kinase 1

1

20

Small-scale

0.647

High

169076

ACTB
Actin, cytoplasmic 1

1

6

Small-scale

0.646

High

169105

IQCE
IQ domain-containing protein E

1

20

High-throughput

0.618

High

156693

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.618

High

169045

MYH7
Myosin-7

1

19

High-throughput

0.618

High

169060

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.618

High

169095

MYLK
Myosin light chain kinase, smooth muscle

1

18

High-throughput

0.618

High

169101

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

13

Small-scale

0.618

High

169123

ASB11
Ankyrin repeat and SOCS box protein 11

1

2

High-throughput

0.618

High

169130

AURKB
Aurora kinase B

1

9

High-throughput

0.618

High

169164

NINL
Ninein-like protein

1

17

High-throughput

0.618

High

169109

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

2

5

Small-scale

0.611

High

169049

MYL6B
Myosin light chain 6B

2

19

High-throughput

0.601

High

169029

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

169147

ANLN
Anillin

2

4

High-throughput

0.584

High

169107

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

2

0

High-throughput

0.580

High

169026

DAPK3
Death-associated protein kinase 3

1

20

Small-scale

0.575

High

169078

ACTA
Actin, aortic smooth muscle

1

7

Small-scale

0.575

High

169115

MY18B
Unconventional myosin-XVIIIb

1

20

High-throughput

0.575

High

169158

MYO5B
Unconventional myosin-Vb

1

13

High-throughput

0.575

High

169072

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.553

High

169125

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

1

Small-scale

0.552

High

169039

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.541

High

164977

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

169025

TIF1A
Transcription intermediary factor 1-alpha

1

12

High-throughput

0.536

High

169079

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.536

High

169089

CUL1
Cullin-1

1

1

High-throughput

0.536

High

169138

SENP7
Sentrin-specific protease 7

1

1

High-throughput

0.536

High

169027

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

169030

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.513

High

169070

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

169087

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.489

High

169113

UBE3B
Ubiquitin-protein ligase E3B

1

11

High-throughput

0.489

High

169122

SETD7
Histone-lysine N-methyltransferase SETD7

1

9

High-throughput

0.489

High

169134

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

169135

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

169140

FOXP1
Forkhead box protein P1

1

4

High-throughput

0.489

High

169157

FOXD3
Forkhead box protein D3

1

2

High-throughput

0.489

High

136743

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

169028

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

169031

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

169032

RHBT1
Rho-related BTB domain-containing protein 1

1

10

High-throughput

0.479

High

169033

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

169034

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

169035

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.479

High

169036

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

169040

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

169042

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

169047

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

169052

LEG3
Galectin-3

1

1

Small-scale

0.479

High

169055

BTF3
Transcription factor BTF3

1

4

High-throughput

0.479

High

169056

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

169057

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.479

High

169058

COF1
Cofilin-1

1

4

High-throughput

0.479

High

169062

1433T
14-3-3 protein theta

1

8

High-throughput

0.479

High

169071

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

169084

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

169091

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

169093

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

169094

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

169096

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

9

High-throughput

0.479

High

169097

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

169108

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

169110

MOB2
MOB kinase activator 2

1

2

High-throughput

0.479

High

169116

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

169121

FBX25
F-box only protein 25

1

2

High-throughput

0.479

High

169128

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

169137

MEP50
Methylosome protein WDR77

1

4

High-throughput

0.479

High

169139

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.479

High

169142

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

169143

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

169144

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

169148

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

169149

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

169152

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

169153

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.479

High

169154

TES
Testin

1

7

High-throughput

0.479

High

169163

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

169166

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

4

Small-scale

0.479

High

169167

CRYL1
Lambda-crystallin homolog

1

1

High-throughput

0.479

High

169169

PHOCN
MOB-like protein phocein

1

2

High-throughput

0.479

High

134967

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

169043

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

169063

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

169067

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

169077

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

169085

CD47
Leukocyte surface antigen CD47

1

0

Small-scale

0.458

High

169090

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

169098

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

169099

MIDN
Midnolin

1

0

High-throughput

0.458

High

169111

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

169129

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.458

High

169132

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

169156

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.458

High

169161

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

169038

FINC
Fibronectin

1

2

High-throughput

0.445

High

169041

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

19

High-throughput

0.445

High

169044

MYL4
Myosin light chain 4

1

18

High-throughput

0.445

High

169046

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

169061

S10A4
Protein S100-A4

1

2

High-throughput

0.445

High

169074

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

169080

RHOG
Rho-related GTP-binding protein RhoG

1

7

Small-scale

0.445

High

169082

LAT1
Large neutral amino acids transporter small subunit 1

1

3

High-throughput

0.445

High

169083

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.445

High

169106

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.445

High

169120

NCKX4
Sodium/potassium/calcium exchanger 4

1

2

High-throughput

0.445

High

169141

UN45A
Protein unc-45 homolog A

1

2

High-throughput

0.445

High

169162

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

169037

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

169086

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.437

High

169112

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

169127

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

169133

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.437

High

169145

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.437

High

169150

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

169048

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

169054

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

169092

BECN1
Beclin-1

1

0

High-throughput

0.426

High

169100

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

169068

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

169081

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.407

High

169146

TPC
Mitochondrial thiamine pyrophosphate carrier

1

3

High-throughput

0.407

High

169155

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.407

High

169160

NAC2
Sodium/calcium exchanger 2

1

2

High-throughput

0.407

High

169168

S45A1
Proton-associated sugar transporter A

1

3

High-throughput

0.407

High

169172

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.407

High

169104

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.279

Low

169118

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.279

Low

169151

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

169170

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

169050

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

169051

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

169117

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

169102

MF14B
Hippocampus abundant transcript-like protein 1

1

0

High-throughput

0.232

Low

169103

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

169136

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025