HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.890

The method score is based on:

Property Details
Experiments 32989298, 18773538, 29764989, 18615013
Identification Methods affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0004672 - protein kinase activity
and 20 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 403
Hs

1 603
+ Hs
+ Hs
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ Zm
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025