Protein: PLK3
Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)

Gene: PLK3
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q9H4B4

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000302 - response to reactive oxygen species
GO:0000776 - kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

355033

CHK2
Serine/threonine-protein kinase Chk2

3

19

Small-scale

0.882

High

719371

MPIP3
M-phase inducer phosphatase 3

2

4

Small-scale

0.843

High

1408476

VRK1
Serine/threonine-protein kinase VRK1

1

16

Small-scale

0.747

High

854294

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.691

High

1402580

SRPK1
SRSF protein kinase 1

1

16

High-throughput

0.691

High

170350

AURKA
Aurora kinase A

1

17

Small-scale

0.647

High

414622

P53
Cellular tumor antigen p53

2

2

Small-scale

0.646

High

777011

PPM1A
Protein phosphatase 1A

1

17

Small-scale

0.621

High

920270

PLK1
Serine/threonine-protein kinase PLK1

1

17

Small-scale

0.621

High

1224909

TENS2
Tensin-2

1

4

Small-scale

0.621

High

471755

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

4

Small-scale

0.618

High

1407512

CIB1
Calcium and integrin-binding protein 1

1

20

Small-scale

0.618

High

1161396

HIF1A
Hypoxia-inducible factor 1-alpha

2

1

Small-scale

0.611

High

848002

RAD52
DNA repair protein RAD52 homolog

2

0

High-throughput

0.580

High

1433391

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

0

High-throughput

0.580

High

576263

PO2F1
POU domain, class 2, transcription factor 1

1

4

High-throughput

0.573

High

251810

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

19

Small-scale

0.561

High

404913

PRIO
Major prion protein

1

1

Small-scale

0.561

High

1358006

RN141
RING finger protein 141

2

1

High-throughput

0.553

High

1151075

PCH2
Pachytene checkpoint protein 2 homolog

1

9

High-throughput

0.541

High

124838

AIP
AH receptor-interacting protein

1

4

High-throughput

0.536

High

542654

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

1245735

LARP1
La-related protein 1

1

2

High-throughput

0.536

High

1433388

MOV10
Helicase MOV-10

1

1

High-throughput

0.536

High

1433390

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.536

High

1025751

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.513

High

1391104

TRM61
tRNA

1

0

High-throughput

0.513

High

106649

APRIO
Alternative prion protein

1

2

Small-scale

0.512

High

791727

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

1060227

B2CL1
Bcl-2-like protein 1

1

1

Small-scale

0.501

High

1156363

SYUB
Beta-synuclein

1

4

Small-scale

0.501

High

1259155

LARP4
La-related protein 4

1

1

High-throughput

0.489

High

725806

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

3

Small-scale

0.481

High

1314418

SLX4
Structure-specific endonuclease subunit SLX4

1

6

Small-scale

0.481

High

211600

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.479

High

430355

JUN
Transcription factor Jun

1

3

Small-scale

0.479

High

1433389

DIP2B
Disco-interacting protein 2 homolog B

1

2

Small-scale

0.479

High

1259026

CENPU
Centromere protein U

1

2

Small-scale

0.408

High

1429130

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025