HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: WDR74 (Q6RFH5)
WD repeat-containing protein 74 (NOP seven-associated protein 1)
Gene: WDR74

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 385
+	Hs
		173321 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TBL1R_HUMAN (82-377): 1.53e-64: 215: 13.59
+	Hs
		172318 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TBL1X_HUMAN (82-377): 1.93e-63: 214: 12.62
+	Xl
		1237683 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		TB1RA_XENLA (82-377): 1.42e-64: 216: 13.59
+	Hs
		173328 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SKI8_HUMAN (94-299): 5.27e-59: 195: 21.26
+	Hs
		173205 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SNR40_HUMAN (2-253): 7.03e-50: 173: 12.06
+	Xl
		1232829 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		SKI8_XENLA (100-323): 6.45e-52: 176: 18.67
+	Hs
		173175 XPO1_HUMAN (1-1071): 0: 1022: 100.00		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Hs
		172647 XPO1_HUMAN (1-1071): 0: 1022: 100.00		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98
+	Sc
		722111 XPO1_YEAST (14-1067): 0: 848: 46.08		NSA1_YEAST (96-353): 1.24e-71: 233: 25.25
+	Xl
		1231406 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6DCY8_XENLA (3-113): 7.12e-13: 71: 5.98
+	Sc
		721870 XPO1_YEAST (14-1067): 0: 848: 46.08		TAF5_YEAST (145-325): 3.26e-12: 70.2: 14.29
+	Hs
		1247299 XPO7_HUMAN (23-1013): 1.49e-120: 398: 13.18		WDR74_HUMAN (1-385): 4.56e-94: 288: 100.00
+	Mm
		1424323 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SKI8_MOUSE (99-299): 4.95e-60: 198: 21.78
+	Hs
		220961 XPOT_HUMAN (29-1023): 3.56e-126: 410: 14.85		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Mm
		965404 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		WDR5_MOUSE (3-113): 5.77e-14: 74.1: 5.98
+	Hs
		1134319 IMB1_HUMAN (27-908): 2.9e-90: 311: 11.32		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39