HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: RND1 (Q92730)
Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)
Gene: RND1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	12730235, 29040270
Identification Methods	two hybrid, isothermal titration calorimetry, molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0007162 - negative regulation of cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1838 Hs			1 232
+	Hs
		175349 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RND3_HUMAN (1-232): 9.61e-101: 294: 58.20
+	Hs
		175337 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RND2_HUMAN (12-232): 9.66e-80: 240: 53.15
+	Hs
		175353 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RAC1_HUMAN (11-200): 6.09e-79: 237: 38.42
+	Hs
		175356 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOG_HUMAN (11-198): 4.17e-78: 234: 37.77
+	Hs
		175316 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RAC2_HUMAN (11-201): 8.33e-76: 229: 38.22
+	Hs
		175345 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RAC3_HUMAN (11-188): 6.07e-76: 229: 39.89
+	Hs
		175348 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOA_HUMAN (15-197): 9.94e-75: 226: 43.17
+	Hs
		175346 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		CDC42_HUMAN (11-198): 1.38e-74: 225: 37.23
+	Hs
		175306 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOC_HUMAN (13-184): 4.61e-50: 163: 46.51
+	Hs
		175351 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOB_HUMAN (13-190): 2.92e-49: 161: 44.94
+	Hs
		126367 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOD_HUMAN (6-189): 1.8e-48: 160: 40.76
+	Hs
		175434 PLXB2_HUMAN (1-1838): 0: 2439: 100.00		RHOF_HUMAN (1-189): 2.34e-44: 149: 40.21
+	Hs
		988807 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RAC1_HUMAN (11-200): 6.09e-79: 237: 38.42
+	Hs
		581364 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RAC2_HUMAN (11-201): 8.33e-76: 229: 38.22
+	Hs
		953748 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RAC3_HUMAN (11-188): 6.07e-76: 229: 39.89
+	Hs
		962615 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RHOA_HUMAN (15-197): 9.94e-75: 226: 43.17
+	Hs
		955733 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		CDC42_HUMAN (11-198): 1.38e-74: 225: 37.23
+	Hs
		466516 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RHOC_HUMAN (13-184): 4.61e-50: 163: 46.51
+	Hs
		978386 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RHOB_HUMAN (13-190): 2.92e-49: 161: 44.94
+	Hs
		126863 PLXA1_HUMAN (12-1831): 0: 2077: 32.31		RHOD_HUMAN (6-189): 1.8e-48: 160: 40.76