Protein: PLXB2
Plexin-B2 (MM1)

Gene: PLXB2, PLXNB2
Organism: Homo sapiens
Interactions: 181
UniProt ID: O15031

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0001932 - regulation of protein phosphorylation
GO:0002116 - semaphorin receptor complex
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126367

RHOD
Rho-related GTP-binding protein RhoD

5

20

High-throughput

0.919

High

175407

RND1
Rho-related GTP-binding protein Rho6

2

20

Small-scale

0.793

High

175337

RND2
Rho-related GTP-binding protein RhoN

2

20

Small-scale

0.789

High

175349

RND3
Rho-related GTP-binding protein RhoE

2

20

Small-scale

0.789

High

175384

BTNL8
Butyrophilin-like protein 8

2

10

High-throughput

0.789

High

175421

SEM4C
Semaphorin-4C

1

20

High-throughput

0.691

High

175448

BTNL2
Butyrophilin-like protein 2

1

15

High-throughput

0.691

High

175360

LMAN2
Vesicular integral-membrane protein VIP36

3

1

High-throughput

0.667

High

175364

PTC1
Protein patched homolog 1

3

9

High-throughput

0.667

High

175393

LYPD6
Ly6/PLAUR domain-containing protein 6

3

1

High-throughput

0.667

High

175307

MET
Hepatocyte growth factor receptor

1

19

Small-scale

0.665

High

175359

RON
Macrophage-stimulating protein receptor

1

20

Small-scale

0.665

High

175428

SEM4A
Semaphorin-4A

1

20

Small-scale

0.647

High

175372

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.646

High

175280

ARHGB
Rho guanine nucleotide exchange factor 11

2

20

Small-scale

0.640

High

175342

DEF1
Neutrophil defensin 1

2

5

High-throughput

0.628

High

175285

SG2A1
Mammaglobin-B

1

5

High-throughput

0.618

High

175291

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.618

High

175385

BTNL3
Butyrophilin-like protein 3

1

10

High-throughput

0.618

High

175294

RASK
GTPase KRas

1

20

High-throughput

0.618

High

175306

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

175316

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

175318

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

175329

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.618

High

175335

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.618

High

175336

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.618

High

175345

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

175346

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

175347

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

175348

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

175351

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

175353

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

175356

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

175369

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

175371

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

175389

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

175429

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

175434

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

175358

DEF5
Defensin alpha 5

3

5

High-throughput

0.604

High

175308

LEG1
Galectin-1

2

8

High-throughput

0.601

High

175297

TRGV3
T cell receptor gamma variable 3

1

1

High-throughput

0.575

High

175309

PGFRB
Platelet-derived growth factor receptor beta

1

19

High-throughput

0.575

High

175404

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

6

High-throughput

0.574

High

175427

TMX1
Thioredoxin-related transmembrane protein 1

2

11

High-throughput

0.574

High

175403

PATE1
Prostate and testis expressed protein 1

2

5

High-throughput

0.549

High

175449

FBX2
F-box only protein 2

2

19

High-throughput

0.549

High

85924

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

10

High-throughput

0.536

High

175288

ECEL1
Endothelin-converting enzyme-like 1

1

2

High-throughput

0.536

High

175319

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

8

High-throughput

0.536

High

175324

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

High-throughput

0.536

High

175338

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

7

High-throughput

0.536

High

175357

IL5RA
Interleukin-5 receptor subunit alpha

1

12

High-throughput

0.536

High

175373

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

17

High-throughput

0.536

High

175382

I27RA
Interleukin-27 receptor subunit alpha

1

8

High-throughput

0.536

High

175387

CDHR3
Cadherin-related family member 3

1

15

High-throughput

0.536

High

175405

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.536

High

175408

GGH
Gamma-glutamyl hydrolase

1

4

High-throughput

0.536

High

175409

T106A
Transmembrane protein 106A

1

8

High-throughput

0.536

High

175411

ASIC4
Acid-sensing ion channel 4

1

4

High-throughput

0.536

High

175420

CNTP3
Contactin-associated protein-like 3

1

8

High-throughput

0.536

High

175450

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

4

High-throughput

0.536

High

175344

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.533

High

175321

PTN
Pleiotrophin

1

0

High-throughput

0.518

High

175325

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

175390

TM11B
Transmembrane protease serine 11B

1

19

High-throughput

0.515

High

175439

TMPS4
Transmembrane protease serine 4

1

18

High-throughput

0.515

High

175392

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

6

High-throughput

0.514

High

175286

S22A3
Solute carrier family 22 member 3

1

0

High-throughput

0.513

High

175292

BY55
CD160 antigen

1

0

High-throughput

0.513

High

175295

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.513

High

175317

TSHR
Thyrotropin receptor

1

0

High-throughput

0.513

High

175394

I17RC
Interleukin-17 receptor C

1

0

High-throughput

0.513

High

175398

ARRD4
Arrestin domain-containing protein 4

1

0

High-throughput

0.513

High

175302

INSR
Insulin receptor

1

20

High-throughput

0.500

High

175305

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.500

High

175289

LY86
Lymphocyte antigen 86

1

6

High-throughput

0.489

High

175290

QORL1
Quinone oxidoreductase-like protein 1

1

1

High-throughput

0.489

High

175299

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

175312

PSPC
Surfactant protein C

1

8

High-throughput

0.489

High

175333

DNSL1
Deoxyribonuclease-1-like 1

1

5

High-throughput

0.489

High

175339

EP3B
Epididymal secretory protein E3-beta

1

6

High-throughput

0.489

High

175341

TMPS3
Transmembrane protease serine 3

1

18

High-throughput

0.489

High

175374

CL12B
C-type lectin domain family 12 member B

1

20

High-throughput

0.489

High

175375

DB135
Beta-defensin 135

1

2

High-throughput

0.489

High

175376

MPPE1
Metallophosphoesterase 1

1

2

High-throughput

0.489

High

175381

BRID5
BRICHOS domain-containing protein 5

1

6

High-throughput

0.489

High

175396

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.489

High

175402

CA054
Uncharacterized protein C1orf54

1

10

High-throughput

0.489

High

175413

ZDH12
Palmitoyltransferase ZDHHC12

1

3

High-throughput

0.489

High

175415

LCFC1
Sperm-egg fusion protein LLCFC1

1

2

High-throughput

0.489

High

175424

CST11
Cystatin-11

1

6

High-throughput

0.489

High

175436

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.489

High

175440

CBLN4
Cerebellin-4

1

14

High-throughput

0.489

High

175328

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.486

High

175281

TMPS2
Transmembrane protease serine 2

1

18

High-throughput

0.479

High

175282

TGON2
Trans-Golgi network integral membrane protein 2

1

16

High-throughput

0.479

High

175293

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

175298

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

175303

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

175304

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

175311

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

175314

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

175315

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

8

High-throughput

0.479

High

175320

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

6

Small-scale

0.479

High

175326

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.479

High

175327

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

175350

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

175352

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.479

High

175363

CUL3
Cullin-3

1

2

High-throughput

0.479

High

175365

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

11

High-throughput

0.479

High

175368

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

17

High-throughput

0.479

High

175370

TLR1
Toll-like receptor 1

1

1

High-throughput

0.479

High

175378

TEN4
Teneurin-4

1

8

High-throughput

0.479

High

175383

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

175386

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

175414

DNJC1
DnaJ homolog subfamily C member 1

1

10

High-throughput

0.479

High

175416

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

175423

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

175430

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

175441

T106B
Transmembrane protein 106B

1

8

High-throughput

0.479

High

175444

ARHGC
Rho guanine nucleotide exchange factor 12

1

16

Small-scale

0.479

High

175451

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

175388

CENPU
Centromere protein U

1

1

High-throughput

0.464

High

175313

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

175377

PVRIG
Transmembrane protein PVRIG

1

0

High-throughput

0.458

High

175418

DERL1
Derlin-1

1

0

High-throughput

0.458

High

175433

SIAE
Sialate O-acetylesterase

1

0

High-throughput

0.458

High

175296

B3AT
Band 3 anion transport protein

1

3

High-throughput

0.445

High

175322

CD9
CD9 antigen

1

2

High-throughput

0.445

High

175331

EAA4
Excitatory amino acid transporter 4

1

2

High-throughput

0.445

High

175332

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.445

High

175343

CD81
CD81 antigen

1

2

High-throughput

0.445

High

175399

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

3

High-throughput

0.445

High

175419

S12A9
Solute carrier family 12 member 9

1

3

High-throughput

0.445

High

175445

SPAST
Spastin

1

2

High-throughput

0.445

High

175330

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

175334

EMD
Emerin

1

1

High-throughput

0.437

High

175362

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.437

High

175395

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

175410

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.437

High

175425

DJC25
DnaJ homolog subfamily C member 25

1

10

High-throughput

0.437

High

175426

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

175431

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

175438

FBX6
F-box only protein 6

1

19

High-throughput

0.437

High

175442

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

175443

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

175446

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

166214

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

175287

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

175323

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.426

High

175361

UT1
Urea transporter 1

1

0

High-throughput

0.426

High

175379

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.426

High

175400

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.426

High

175406

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

175435

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

175452

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

94391

D6RAP2
Toll like receptor 1

1

6

High-throughput

0.407

High

170555

CLGN
Calmegin

1

12

High-throughput

0.407

High

175310

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

1

High-throughput

0.407

High

175340

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

3

High-throughput

0.407

High

175355

DLK1
Protein delta homolog 1

1

12

High-throughput

0.407

High

175380

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.407

High

175397

SPX3
Sugar phosphate exchanger 3

1

2

High-throughput

0.407

High

175432

ZDH11
Palmitoyltransferase ZDHHC11

1

3

High-throughput

0.407

High

66780

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.279

Low

175367

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

175401

TMED6
Transmembrane emp24 domain-containing protein 6

1

0

High-throughput

0.279

Low

175447

SRGEF
Secretion-regulating guanine nucleotide exchange factor

1

0

High-throughput

0.279

Low

175453

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

175284

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

173773

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.249

Low

175283

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.249

Low

175300

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

175301

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

175354

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

175366

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.249

Low

175391

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

175417

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.249

Low

175422

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.249

Low

175437

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

175412

BSCL2
Seipin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025