HitPredict

Interactor 1: EIF3D (O15371)
Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)
Gene: EIF3D

Interactor 2: EIF3C (Q99613)
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)
Gene: EIF3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

The method score is based on:

Property	Details
Experiments	33961781, 35235311, 24981860, 22190034, 23623729, 18628297
Identification Methods	affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	eIF-3_zeta~eIF-3c_N
Common GO terms	GO:0001732 - formation of cytoplasmic translation initiation complex GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0005852 - eukaryotic translation initiation factor 3 complex and 5 others more... GO:0006413 - translational initiation GO:0016282 - eukaryotic 43S preinitiation complex GO:0033290 - eukaryotic 48S preinitiation complex GO:0045727 - positive regulation of translation GO:1902416 - positive regulation of mRNA binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	548
Hs

1	913

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024