HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: NR2C1 (P13056)
Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2)
Gene: NR2C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	14521922, 12943985, 11463856, 19204783, 21670149
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 603
+	Hs
		525310 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2C1_HUMAN (1-603): 1.16e-165: 487: 100.00
+	Hs
		177232 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR2C2_HUMAN (11-603): 4.85e-143: 429: 59.80
+	Hs
		823977 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2C2_HUMAN (11-603): 4.85e-143: 429: 59.80
+	Hs
		177193 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR1D1_HUMAN (36-573): 3.83e-90: 292: 18.59
+	Hs
		1038387 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR1D2_HUMAN (89-573): 4.42e-93: 299: 19.96
+	Hs
		846410 HDAC1_HUMAN (3-385): 0: 588: 62.92		RORG_HUMAN (112-591): 1.08e-92: 296: 20.97
+	Mm
		292408 HDAC3_MOUSE (1-428): 0: 601: 99.77		RORA_MOUSE (64-590): 4.68e-86: 279: 19.33
+	Hs
		1030585 HDAC1_HUMAN (3-385): 0: 588: 62.92		STF1_HUMAN (106-592): 1.54e-90: 289: 20.74
+	Hs
		177303 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR0B2_HUMAN (369-587): 3.69e-69: 226: 25.89
+	Hs
		1038404 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR0B2_HUMAN (369-587): 3.69e-69: 226: 25.89
+	Hs
		177191 HDAC3_HUMAN (1-428): 0: 600: 100.00		RXRA_HUMAN (24-276): 5.47e-50: 181: 25.00
+	Mm
		140236 HDAC1_MOUSE (3-385): 0: 588: 62.92		RXRA_MOUSE (23-276): 2.07e-50: 182: 25.67
+	Mm
		292417 HDAC3_MOUSE (1-428): 0: 601: 99.77		NR2E1_MOUSE (100-259): 1.64e-45: 167: 32.37
+	Hs
		177412 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR2E1_HUMAN (100-259): 3.79e-45: 166: 31.79
+	Hs
		177223 HDAC3_HUMAN (1-428): 0: 600: 100.00		HNF4A_HUMAN (59-228): 7.55e-43: 162: 33.53
+	Hs
		1038843 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2E1_HUMAN (100-259): 3.79e-45: 166: 31.79
+	Hs
		622790 HDAC1_HUMAN (3-385): 0: 588: 62.92		COT2_HUMAN (51-189): 1.15e-44: 165: 42.45
+	Hs
		177175 HDAC3_HUMAN (1-428): 0: 600: 100.00		RARA_HUMAN (108-187): 2.85e-27: 117: 60.00
+	Hs
		177299 HDAC3_HUMAN (1-428): 0: 600: 100.00		Q15156_HUMAN (108-187): 2.68e-26: 116: 60.00
+	Hs
		487964 HDAC1_HUMAN (3-385): 0: 588: 62.92		RARA_HUMAN (108-187): 2.85e-27: 117: 60.00