HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22989952
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 181
+	Mm
		1141349 Q9JM08_MOUSE (1-428): 0: 595: 99.07		ATF3_MOUSE (1-181): 6.94e-41: 137: 95.03
+	Hs
		579204 HDAC1_HUMAN (3-385): 0: 588: 62.92		ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00
+	Mm
		936396 HDAC2_MOUSE (3-422): 0: 578: 58.39		ATF3_MOUSE (1-181): 6.94e-41: 137: 95.03
+	Hs
		177168 HDAC3_HUMAN (1-428): 0: 600: 100.00		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Mm
		140216 HDAC1_MOUSE (3-385): 0: 588: 62.92		JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37
+	Mm
		404159 Q9JM08_MOUSE (1-428): 0: 595: 99.07		JUN_MOUSE (10-155): 1.94e-23: 96.5: 19.46
+	Dm
		599218 HDAC1_DROME (3-422): 0: 580: 56.74		FOSLA_DROME (4-163): 3.4e-27: 108: 23.13
+	Mm
		450547 HDAC2_MOUSE (3-422): 0: 578: 58.39		JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37
+	Hs
		401956 HDAC1_HUMAN (3-385): 0: 588: 62.92		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Hs
		345504 HDAC2_HUMAN (3-422): 0: 580: 58.63		FOS_HUMAN (14-158): 2.36e-25: 102: 26.25
+	Hs
		548245 HDAC1_HUMAN (3-385): 0: 588: 62.92		FOSL1_HUMAN (42-169): 1.11e-22: 93.4: 26.76
+	Mm
		957049 Q9JM08_MOUSE (1-428): 0: 595: 99.07		JDP2_MOUSE (73-176): 1.09e-20: 85.3: 60.58
+	Hs
		402302 HDAC2_HUMAN (3-422): 0: 580: 58.63		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Hs
		1038579 HDAC1_HUMAN (3-385): 0: 588: 62.92		JDP2_HUMAN (73-176): 1.03e-20: 85.7: 59.62
+	Mm
		140255 HDAC1_MOUSE (3-385): 0: 588: 62.92		JDP2_MOUSE (73-176): 1.09e-20: 85.3: 60.58
+	Dm
		576068 HDAC1_DROME (3-422): 0: 580: 56.74		JRA_DROME (13-159): 1.51e-21: 90.3: 19.60
+	Mm
		526735 HDAC2_MOUSE (3-422): 0: 578: 58.39		FOSB_MOUSE (96-163): 9.36e-20: 86.4: 45.59
+	Mm
		936382 HDAC2_MOUSE (3-422): 0: 578: 58.39		JDP2_MOUSE (73-176): 1.09e-20: 85.3: 60.58
+	Sp
		223487 CLR6_SCHPO (3-403): 0: 541: 57.61		ATF1_SCHPO (7-171): 3.47e-26: 105: 20.48
+	Ce
		105173 HDA1_CAEEL (3-427): 0: 550: 53.92		FOS1_CAEEL (11-160): 5.09e-22: 93.8: 18.00