HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: KLF6 (Q99612)
Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)
Gene: KLF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15917248
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 283
+	Mm
		1207125 Q9JM08_MOUSE (1-428): 0: 595: 99.07		Q8BPQ2_MOUSE (1-283): 3.25e-97: 290: 94.72
+	Mm
		140295 HDAC1_MOUSE (3-385): 0: 588: 62.92		Q8BPQ2_MOUSE (1-283): 3.25e-97: 290: 94.72
+	Hs
		177170 HDAC3_HUMAN (1-428): 0: 600: 100.00		SP1_HUMAN (103-282): 8.67e-58: 199: 33.18
+	Mm
		292670 Q9JM08_MOUSE (1-428): 0: 595: 99.07		SP1_MOUSE (103-282): 8.12e-56: 193: 32.43
+	Hs
		435085 HDAC1_HUMAN (3-385): 0: 588: 62.92		SP1_HUMAN (103-282): 8.67e-58: 199: 33.18
+	Mm
		140208 HDAC1_MOUSE (3-385): 0: 588: 62.92		SP3_MOUSE (20-282): 1.75e-55: 193: 26.89
+	Mm
		140212 HDAC1_MOUSE (3-385): 0: 588: 62.92		SP1_MOUSE (103-282): 8.12e-56: 193: 32.43
+	Hs
		435149 HDAC2_HUMAN (3-422): 0: 580: 58.63		SP1_HUMAN (103-282): 8.67e-58: 199: 33.18
+	Hs
		970913 HDAC1_HUMAN (3-385): 0: 588: 62.92		SP3_HUMAN (20-282): 6.13e-55: 191: 26.89
+	Hs
		970932 HDAC2_HUMAN (3-422): 0: 580: 58.63		SP3_HUMAN (20-282): 6.13e-55: 191: 26.89
+	Hs
		177373 HDAC3_HUMAN (1-428): 0: 600: 100.00		ZSA5A_HUMAN (42-282): 3.88e-47: 166: 24.36
+	Mm
		140320 HDAC1_MOUSE (3-385): 0: 588: 62.92		KLF5_MOUSE (137-282): 4.83e-49: 169: 54.42
+	Hs
		1032214 HDAC1_HUMAN (3-385): 0: 588: 62.92		KLF1_HUMAN (179-283): 1.76e-48: 166: 65.71
+	Hs
		204176 HDAC1_HUMAN (3-385): 0: 588: 62.92		KLF4_HUMAN (163-283): 8.49e-47: 165: 61.16
+	Hs
		1038360 HDAC1_HUMAN (3-385): 0: 588: 62.92		KLF5_HUMAN (137-282): 9.28e-47: 164: 52.06
+	Hs
		316950 HDAC2_HUMAN (3-422): 0: 580: 58.63		KLF8_HUMAN (93-282): 1.29e-50: 171: 44.85
+	Hs
		204206 HDAC2_HUMAN (3-422): 0: 580: 58.63		KLF4_HUMAN (163-283): 8.49e-47: 165: 61.16
+	Hs
		157899 HDAC1_HUMAN (3-385): 0: 588: 62.92		KLF11_HUMAN (196-283): 3.24e-32: 125: 67.05
+	Mm
		140314 HDAC1_MOUSE (3-385): 0: 588: 62.92		KLF13_MOUSE (197-282): 3.92e-30: 116: 62.79
+	Hs
		1038377 HDAC1_HUMAN (3-385): 0: 588: 62.92		ZN273_HUMAN (51-228): 3.64e-18: 85.9: 10.62