Protein: PKHG6
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)

Gene: PKHG6, PLEKHG6
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q3KR16

Gene Ontology (top 5):
GO:0000922 - spindle pole
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1186383

CEP55
Centrosomal protein of 55 kDa

4

1

High-throughput

0.698

High

962108

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

988408

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

442334

GELS
Gelsolin

2

7

High-throughput

0.628

High

952866

ACTB
Actin, cytoplasmic 1

2

16

High-throughput

0.628

High

977711

ACTA
Actin, aortic smooth muscle

2

10

High-throughput

0.628

High

1186384

PKHG4
Puratrophin-1

1

19

High-throughput

0.618

High

1186388

CARME
Carnosine N-methyltransferase

2

0

High-throughput

0.602

High

151

A0A024R6X4
PLEKHG4

1

19

High-throughput

0.575

High

370076

CYTS
Cystatin-S

2

3

High-throughput

0.574

High

370201

CYTN
Cystatin-SN

2

3

High-throughput

0.574

High

1186396

PCDG5
Protocadherin gamma-A5

2

1

High-throughput

0.574

High

165342

PSA7
Proteasome subunit alpha type-7

2

1

High-throughput

0.571

High

167609

GIPC1
PDZ domain-containing protein GIPC1

2

5

High-throughput

0.571

High

552602

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

2

High-throughput

0.571

High

775551

NU214
Nuclear pore complex protein Nup214

2

8

High-throughput

0.571

High

920818

ACLY
ATP-citrate synthase

2

3

High-throughput

0.571

High

1105616

GOGA4
Golgin subfamily A member 4

2

18

High-throughput

0.571

High

1127809

KRT81
Keratin, type II cuticular Hb1

2

2

High-throughput

0.571

High

402942

ANXA1
Annexin A1

1

4

High-throughput

0.536

High

701993

TMOD1
Tropomodulin-1

1

11

High-throughput

0.536

High

1186395

LIMA1
LIM domain and actin-binding protein 1

1

13

High-throughput

0.536

High

211332

RFOX2
RNA binding protein fox-1 homolog 2

2

9

High-throughput

0.521

High

418172

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

1

High-throughput

0.521

High

1186389

SMRC2
SWI/SNF complex subunit SMARCC2

2

5

High-throughput

0.521

High

1186390

FUBP1
Far upstream element-binding protein 1

2

12

High-throughput

0.521

High

702398

CYTD
Cystatin-D

1

3

High-throughput

0.489

High

1186393

TMOD2
Tropomodulin-2

1

13

High-throughput

0.489

High

431150

LA
Lupus La protein

1

9

High-throughput

0.479

High

1014901

ARF1
ADP-ribosylation factor 1

1

4

High-throughput

0.479

High

935883

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.437

High

1186394

DHCR7
7-dehydrocholesterol reductase

1

2

High-throughput

0.437

High

379649

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

378689

IGJ
Immunoglobulin J chain

2

0

High-throughput

0.328

High

1186391

PAUF
Pancreatic adenocarcinoma up-regulated factor

2

0

High-throughput

0.328

High

1186392

BPIA2
BPI fold-containing family A member 2

2

0

High-throughput

0.328

High

1186386

RM14
Large ribosomal subunit protein uL14m

2

0

High-throughput

0.298

High

517230

AMY1B
Alpha-amylase 1B

2

0

High-throughput

0.288

High

378995

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

1186385

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.279

Low

1186387

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025