HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 248
+	Hs
		179602 MUSK_HUMAN (1-869): 0: 786: 100.00		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		720182 UFO_HUMAN (2-868): 2.36e-152: 471: 20.71		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		971456 MERTK_HUMAN (102-868): 2.19e-145: 456: 22.14		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	At
		1375563 SERK1_ARATH (311-869): 3.13e-141: 434: 17.43		14337_ARATH (2-247): 4.37e-147: 413: 58.07
+	At
		1030873 BAK1_ARATH (290-868): 2.81e-140: 431: 17.72		14332_ARATH (3-248): 2.24e-144: 405: 58.47
+	Hs
		690954 MERTK_HUMAN (102-868): 2.19e-145: 456: 22.14		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		720144 UFO_HUMAN (2-868): 2.36e-152: 471: 20.71		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		729787 MERTK_HUMAN (102-868): 2.19e-145: 456: 22.14		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		439660 INSR_HUMAN (569-857): 8.77e-70: 254: 42.22		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		465425 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		465471 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		465479 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		641153 FGFR2_HUMAN (21-329): 8.5e-69: 246: 20.05		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		465413 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		439659 INSR_HUMAN (569-857): 8.77e-70: 254: 42.22		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		465424 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		465468 IGF1R_HUMAN (569-852): 1.94e-69: 253: 42.96		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Hs
		641129 FGFR2_HUMAN (21-329): 8.5e-69: 246: 20.05		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Dm
		479708 INSR_DROME (539-864): 7.88e-66: 243: 38.34		1433Z_DROME (1-245): 4.73e-99: 290: 66.12
+	Hs
		648437 FGFR4_HUMAN (569-859): 7.12e-66: 237: 43.88		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62