HitPredict

Interactor 1: CCL16 (O15467)
C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
Gene: CCL16

Interactor 2: CCR2 (P41597)
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Gene: CCR2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	11470772
Identification Methods	biochemical, fluorescence technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0002548 - monocyte chemotaxis GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 120 Hs			1 374
+	Hs
		783833 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR2_HUMAN (1-374): 5.63e-99: 299: 100.00
+	Hs
		849619 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR3_HUMAN (21-320): 2.71e-96: 292: 53.77
+	Hs
		561732 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR3_HUMAN (21-320): 2.71e-96: 292: 53.77
+	Hs
		526564 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR3_HUMAN (21-320): 2.71e-96: 292: 53.77
+	Hs
		180162 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR8_HUMAN (10-325): 3.08e-89: 274: 40.00
+	Hs
		1305163 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR4_HUMAN (15-319): 7.04e-86: 265: 32.26
+	Hs
		134400 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR2_HUMAN (2-332): 4.99e-84: 262: 35.29
+	Hs
		134356 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		ACKR2_HUMAN (2-332): 4.99e-84: 262: 35.29
+	Hs
		180158 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR1_HUMAN (24-356): 1.93e-73: 234: 53.85
+	Hs
		180161 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR5_HUMAN (13-352): 3.44e-70: 225: 68.41
+	Mm
		500591 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR3_MOUSE (20-349): 2.1e-74: 236: 52.98
+	Hs
		561728 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR1_HUMAN (24-356): 1.93e-73: 234: 53.85
+	Hs
		526560 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR1_HUMAN (24-356): 1.93e-73: 234: 53.85
+	Hs
		849654 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR5_HUMAN (13-352): 3.44e-70: 225: 68.41
+	Hs
		561733 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR5_HUMAN (13-352): 3.44e-70: 225: 68.41
+	Hs
		526565 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR5_HUMAN (13-352): 3.44e-70: 225: 68.41
+	Mm
		500590 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR1_MOUSE (21-349): 5.13e-66: 214: 50.15
+	Hs
		180159 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CXCR5_HUMAN (42-314): 4.74e-47: 166: 33.33
+	Hs
		830629 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CXCR3_HUMAN (63-322): 1.46e-50: 174: 34.96
+	Hs
		526561 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CXCR5_HUMAN (42-314): 4.74e-47: 166: 33.33