HitPredict

Interactor 1: LRAD4 (O15165)
Low-density lipoprotein receptor class A domain-containing protein 4
Gene: LDLRAD4

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.630

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 306 Hs			1 1572
+	Hs
		181002 LRAD4_HUMAN (1-306): 0: 578: 100.00		HECW1_HUMAN (1-1572): 0: 1165: 55.24
+	Hs
		181021 LRAD4_HUMAN (1-306): 0: 578: 100.00		SMUF2_HUMAN (177-504): 3.44e-45: 178: 13.83
+	Hs
		180983 LRAD4_HUMAN (1-306): 0: 578: 100.00		NEDD4_HUMAN (265-596): 3e-21: 103: 10.88
+	Hs
		181014 LRAD4_HUMAN (1-306): 0: 578: 100.00		NED4L_HUMAN (616-1033): 3.07e-17: 90.1: 14.48
+	Hs
		131580 LRAD4_HUMAN (1-306): 0: 578: 100.00		WWP2_HUMAN (665-1078): 1.98e-14: 80.8: 16.39
+	Hs
		181019 LRAD4_HUMAN (1-306): 0: 578: 100.00		WWP1_HUMAN (616-1034): 1.14e-13: 78.5: 15.33
+	Hs
		181013 LRAD4_HUMAN (1-306): 0: 578: 100.00		ITCH_HUMAN (166-495): 1.4e-12: 75.1: 12.93
+	Hs
		181022 LRAD4_HUMAN (1-306): 0: 578: 100.00		SMUF1_HUMAN (680-902): 1.41e-12: 74.7: 15.19
+	Hs
		861710 PMEPA_HUMAN (57-304): 1.13e-133: 382: 66.14		NEDD4_HUMAN (265-596): 3e-21: 103: 10.88
+	Hs
		1381450 PMEPA_HUMAN (57-304): 1.13e-133: 382: 66.14		NED4L_HUMAN (616-1033): 3.07e-17: 90.1: 14.48
+	Mm
		59719 A2APF4_MOUSE (56-302): 2.8e-124: 358: 64.54		NEDD4_MOUSE (625-851): 1.83e-11: 71.2: 13.58
+	Mm
		861897 PMEPA_MOUSE (56-302): 1.2e-122: 353: 64.54		NEDD4_MOUSE (625-851): 1.83e-11: 71.2: 13.58