HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: TIE2 (Q02763)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Gene: TEK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29991678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1124
+	Hs
		181803 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		UFO_HUMAN (330-1106): 3.07e-162: 505: 23.47
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (350-1118): 1.89e-157: 490: 24.44
+	Hs
		855777 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		EPHA4_HUMAN (423-1124): 1.05e-160: 504: 21.99
+	Hs
		411613 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		UFO_HUMAN (330-1106): 3.07e-162: 505: 23.47
+	Hs
		208998 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		UFO_HUMAN (330-1106): 3.07e-162: 505: 23.47
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (350-1118): 1.89e-157: 490: 24.44
+	Hs
		146597 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		EPHA2_HUMAN (442-1123): 7.37e-153: 483: 22.10
+	Hs
		147489 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		EPHA2_HUMAN (442-1123): 7.37e-153: 483: 22.10
+	Hs
		208993 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		FGFR4_HUMAN (338-1123): 5.05e-157: 488: 23.99
+	Hs
		411611 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		EPHA2_HUMAN (442-1123): 7.37e-153: 483: 22.10
+	Hs
		208983 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		FGFR1_HUMAN (362-1124): 2.97e-155: 484: 23.82
+	Hs
		208996 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		EPHA2_HUMAN (442-1123): 7.37e-153: 483: 22.10
+	Hs
		208997 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		EPHA8_HUMAN (519-1110): 2.23e-152: 483: 21.58
+	Hs
		445884 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ROS1_HUMAN (448-1123): 1.09e-128: 437: 24.41
+	Dm
		526800 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		7LESS_DROME (386-1122): 1.08e-123: 422: 24.29
+	Hs
		208976 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		RET_HUMAN (830-1104): 6.46e-68: 251: 45.02
+	Dm
		1360390 SRC42_DROME (64-202): 6.56e-39: 141: 19.44		CAD96_DROME (824-1116): 1.36e-67: 244: 39.80
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (813-1098): 5.99e-56: 214: 38.51
+	Dm
		337641 ABL_DROME (14-193): 2.41e-38: 142: 14.06		ABL_DROME (813-1098): 1.32e-56: 217: 38.85
+	Mm
		337630 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		ABL1_MOUSE (813-1098): 3.66e-56: 214: 39.19