HitPredict

Interactor 1: MES2 (O17514)
Histone-lysine N-methyltransferase mes-2 (EC 2.1.1.356) (E(z) homolog) (Maternal-effect sterile protein 2)
Gene: mes-2

Interactor 2: MES6 (Q9GYS1)
Polycomb protein mes-6 (ESC homolog) (Maternal-effect sterile protein 6)
Gene: mes-6

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.882

The method score is based on:

Property Details
Experiments 16055700, 11320248, 15380065
Identification Methods biochemical, enzymatic study, affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~WD40
Common GO terms GO:0000786 - nucleosome
GO:0010468 - regulation of gene expression
GO:0010629 - negative regulation of gene expression
GO:0031519 - PcG protein complex
GO:0035098 - ESC/E(Z) complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 773
Ce

1 459
+ At
+ At
+ At
+ Hs
+ Hs
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024