HitPredict

Interactor 1: E9PTH2 (E9PTH2)
Mitogen-activated protein kinase (EC 2.7.11.24)
Gene: Mapk7

Interactor 2: HS90B (P34058)
Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84)
Gene: Hsp90ab1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23428871
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 812 Rn			1 724
+	Mm
		547288 MK07_MOUSE (1-812): 0: 657: 97.41		HS90B_MOUSE (1-724): 0: 1083: 100.00
+	Hs
		468327 MK07_HUMAN (1-812): 0: 641: 88.37		HS90B_HUMAN (1-724): 0: 1080: 99.59
+	Hs
		461431 MK07_HUMAN (1-812): 0: 641: 88.37		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Hs
		573456 MK07_HUMAN (1-812): 0: 641: 88.37		ENPL_HUMAN (3-696): 0: 912: 46.38
+	Hs
		468416 MK14_HUMAN (41-388): 1.15e-150: 447: 45.40		HS90B_HUMAN (1-724): 0: 1080: 99.59
+	Hs
		461525 MK14_HUMAN (41-388): 1.15e-150: 447: 45.40		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Hs
		468095 MK03_HUMAN (26-390): 1.75e-143: 429: 48.22		HS90B_HUMAN (1-724): 0: 1080: 99.59
+	Rn
		639932 MK03_RAT (26-396): 2.23e-142: 426: 47.17		HS90B_RAT (1-724): 0: 1083: 100.00
+	Mm
		462108 MK01_MOUSE (33-394): 9.68e-147: 437: 48.07		HS90A_MOUSE (1-724): 0: 1062: 84.72
+	Hs
		461171 MK03_HUMAN (26-390): 1.75e-143: 429: 48.22		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Rn
		639975 MK03_RAT (26-396): 2.23e-142: 426: 47.17		HS90A_RAT (1-724): 0: 1064: 84.86
+	Mm
		462122 MK03_MOUSE (26-390): 2.23e-142: 426: 47.95		HS90A_MOUSE (1-724): 0: 1062: 84.72
+	At
		908261 MPK10_ARATH (7-391): 1.87e-142: 427: 43.26		HS903_ARATH (10-724): 0: 1000: 66.71
+	Sc
		578785 FUS3_YEAST (47-385): 1.09e-150: 446: 48.29		HSC82_YEAST (13-724): 0: 920: 60.36
+	Sc
		392421 HOG1_YEAST (33-390): 1.76e-144: 434: 44.41		HSP82_YEAST (12-724): 0: 924: 61.40
+	Sc
		393181 SLT2_YEAST (33-500): 6.37e-144: 434: 39.03		HSP82_YEAST (12-724): 0: 924: 61.40
+	Sc
		579044 HOG1_YEAST (33-390): 1.76e-144: 434: 44.41		HSC82_YEAST (13-724): 0: 920: 60.36
+	Rn
		640045 MK03_RAT (26-396): 2.23e-142: 426: 47.17		ENPL_RAT (3-696): 0: 917: 45.82
+	Dm
		823690 ERKA_DROME (37-394): 1.74e-142: 426: 48.88		Q9VAY2_DROME (4-692): 0: 844: 46.29
+	Sc
		392135 KSS1_YEAST (47-361): 4.48e-104: 327: 51.69		HSP82_YEAST (12-724): 0: 924: 61.40