HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: A16L1 (Q676U5)
Autophagy-related protein 16-1 (APG16-like 1)
Gene: ATG16L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31015422
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0051020 - GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 607
+	Hs
		1109815 HDAC1_HUMAN (3-385): 0: 588: 62.92		A16L1_HUMAN (1-607): 2.11e-166: 489: 100.00
+	Hs
		1227186 HDAC2_HUMAN (3-422): 0: 580: 58.63		A16L1_HUMAN (1-607): 2.11e-166: 489: 100.00
+	Hs
		1227626 HDAC6_HUMAN (5-320): 3.51e-103: 333: 23.24		A16L1_HUMAN (1-607): 2.11e-166: 489: 100.00
+	Hs
		188229 HDAC3_HUMAN (1-428): 0: 600: 100.00		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Hs
		1368046 HDAC2_HUMAN (3-422): 0: 580: 58.63		SNR40_HUMAN (175-514): 4.64e-64: 216: 16.81
+	Hs
		964922 HDAC1_HUMAN (3-385): 0: 588: 62.92		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Hs
		965127 HDAC2_HUMAN (3-422): 0: 580: 58.63		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Dm
		1269416 Q7KTS4_DROME (3-427): 0: 550: 65.67		EBI_DROME (254-478): 1.49e-54: 199: 19.17
+	Dm
		1377789 Q9VNC2_DROME (3-427): 0: 546: 65.44		EBI_DROME (254-478): 1.49e-54: 199: 19.17
+	Hs
		188125 HDAC3_HUMAN (1-428): 0: 600: 100.00		TBL1X_HUMAN (468-607): 8.64e-25: 110: 19.87
+	Hs
		188361 HDAC3_HUMAN (1-428): 0: 600: 100.00		TBL1R_HUMAN (479-607): 3.68e-24: 108: 18.71
+	Mm
		148721 HDAC1_MOUSE (3-385): 0: 588: 62.92		A16L1_MOUSE (436-605): 1.39e-26: 116: 15.25
+	Hs
		261406 HDAC1_HUMAN (3-385): 0: 588: 62.92		TBL1X_HUMAN (468-607): 8.64e-25: 110: 19.87
+	Hs
		1110051 HDAC1_HUMAN (3-385): 0: 588: 62.92		TBL1R_HUMAN (479-607): 3.68e-24: 108: 18.71
+	Mm
		1000026 HDAC2_MOUSE (3-422): 0: 578: 58.39		A16L1_MOUSE (436-605): 1.39e-26: 116: 15.25
+	Hs
		261430 HDAC2_HUMAN (3-422): 0: 580: 58.63		TBL1X_HUMAN (468-607): 8.64e-25: 110: 19.87
+	Hs
		1368100 HDAC2_HUMAN (3-422): 0: 580: 58.63		TBL1R_HUMAN (479-607): 3.68e-24: 108: 18.71
+	Hs
		984317 HDAC6_HUMAN (5-320): 3.51e-103: 333: 23.24		GBB2_HUMAN (164-516): 1.54e-55: 193: 16.30
+	Hs
		983606 HDAC6_HUMAN (5-320): 3.51e-103: 333: 23.24		GBB1_HUMAN (165-516): 2.35e-43: 160: 17.18
+	Hs
		1437753 HDAC6_HUMAN (5-320): 3.51e-103: 333: 23.24		GBB4_HUMAN (165-516): 2.18e-42: 157: 16.07