HitPredict

Interactor 1: CCL16 (O15467)
C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
Gene: CCL16

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11470772
Identification Methods	fluorescence technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 120 Hs			1 352
+	Hs
		191478 CCL16_HUMAN (1-120): 3.5e-39: 129: 100.00		CCR8_HUMAN (1-348): 2e-92: 281: 41.08
+	Hs
		191474 CCL16_HUMAN (1-120): 3.5e-39: 129: 100.00		CCR1_HUMAN (12-352): 5.34e-80: 250: 57.02
+	Hs
		906999 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00
+	Hs
		1405933 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		ACKR4_HUMAN (2-340): 9.82e-83: 256: 30.35
+	Hs
		191476 CCL16_HUMAN (1-120): 3.5e-39: 129: 100.00		CCR2_HUMAN (4-327): 3.93e-78: 245: 72.22
+	Hs
		598257 CL3L1_HUMAN (1-95): 2.38e-34: 115: 34.38		CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00
+	Hs
		561030 CCL4_HUMAN (1-94): 7.46e-34: 114: 38.95		CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00
+	Hs
		598252 CL3L1_HUMAN (1-95): 2.38e-34: 115: 34.38		CCR1_HUMAN (12-352): 5.34e-80: 250: 57.02
+	Hs
		561025 CCL4_HUMAN (1-94): 7.46e-34: 114: 38.95		CCR1_HUMAN (12-352): 5.34e-80: 250: 57.02
+	Hs
		835495 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		CCR2_HUMAN (4-327): 3.93e-78: 245: 72.22
+	Mm
		533457 CCL3_MOUSE (1-95): 9.38e-34: 114: 37.50		CCR3_MOUSE (5-352): 5.57e-79: 247: 55.01
+	Hs
		191475 CCL16_HUMAN (1-120): 3.5e-39: 129: 100.00		CXCR5_HUMAN (7-346): 5.01e-69: 222: 26.74
+	Mm
		533456 CCL3_MOUSE (1-95): 9.38e-34: 114: 37.50		CCR1_MOUSE (4-352): 9.92e-73: 231: 54.86
+	Hs
		906964 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		CCR3_HUMAN (1-352): 1.19e-68: 220: 50.43
+	Hs
		561026 CCL4_HUMAN (1-94): 7.46e-34: 114: 38.95		CXCR5_HUMAN (7-346): 5.01e-69: 222: 26.74
+	Hs
		598256 CL3L1_HUMAN (1-95): 2.38e-34: 115: 34.38		CCR3_HUMAN (1-352): 1.19e-68: 220: 50.43
+	Hs
		561029 CCL4_HUMAN (1-94): 7.46e-34: 114: 38.95		CCR3_HUMAN (1-352): 1.19e-68: 220: 50.43
+	Hs
		141857 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		ACKR2_HUMAN (20-312): 2.56e-52: 179: 37.97
+	Hs
		141812 CCL4_HUMAN (1-94): 7.46e-34: 114: 38.95		ACKR2_HUMAN (20-312): 2.56e-52: 179: 37.97
+	Hs
		886123 CCL13_HUMAN (1-99): 3.3e-35: 118: 31.00		CXCR3_HUMAN (16-308): 2.76e-47: 165: 36.49