HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: BACD1 (Q8WZ19)
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein)
Gene: KCTD13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031267 - small GTPase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 329
+	Hs
		598316 FLNA_HUMAN (1-2647): 0: 2776: 100.00		BACD3_HUMAN (11-324): 1.53e-119: 348: 67.41
+	Hs
		598355 FLNA_HUMAN (1-2647): 0: 2776: 100.00		KCND2_HUMAN (1-237): 1.91e-65: 218: 18.93
+	Hs
		598229 FLNA_HUMAN (1-2647): 0: 2776: 100.00		KCD17_HUMAN (41-192): 1.02e-40: 146: 28.93
+	Hs
		598194 FLNA_HUMAN (1-2647): 0: 2776: 100.00		KCTD9_HUMAN (14-166): 7.06e-35: 132: 33.33
+	Hs
		261290 FLNB_HUMAN (28-2647): 0: 2710: 69.63		KCTD9_HUMAN (14-166): 7.06e-35: 132: 33.33
+	Hs
		1045918 FLNC_HUMAN (32-2647): 0: 1432: 35.96		BACD2_HUMAN (23-329): 7.29e-132: 379: 64.50
+	Hs
		1052911 FLNC_HUMAN (32-2647): 0: 1432: 35.96		BACD1_HUMAN (21-329): 1.81e-122: 356: 100.00
+	Hs
		1052954 FLNC_HUMAN (32-2647): 0: 1432: 35.96		KCND2_HUMAN (1-237): 1.91e-65: 218: 18.93
+	Hs
		963357 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		KCTD9_HUMAN (14-166): 7.06e-35: 132: 33.33
+	Hs
		521580 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		KCTD6_HUMAN (40-215): 1.51e-41: 146: 28.25
+	Hs
		70404 B2R8Y4_HUMAN (30-460): 2.45e-118: 401: 25.28		KCTD6_HUMAN (40-215): 1.51e-41: 146: 28.25
+	Hs
		993276 ACTN3_HUMAN (30-460): 2.85e-118: 401: 25.28		KCTD6_HUMAN (40-215): 1.51e-41: 146: 28.25
+	Ce
		1095233 Q23158_CAEEL (23-268): 6.21e-105: 362: 32.93		Q9TZA6_CAEEL (36-226): 2.3e-52: 173: 32.00
+	Ce
		954549 Q23158_CAEEL (23-268): 6.21e-105: 362: 32.93		P91563_CAEEL (40-211): 6e-47: 160: 31.61
+	Hs
		211604 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		KCTD9_HUMAN (14-166): 7.06e-35: 132: 33.33
+	Dm
		1364784 FLNA_DROME (2539-2646): 9.6e-12: 73.5: 28.57		Q9W579_DROME (29-169): 6.32e-41: 143: 26.71