Protein: ACKR2
Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)

Gene: ACKR2
Organism: Homo sapiens
Interactions: 85
UniProt ID: O00590

Gene Ontology (top 5):
GO:0004950 - chemokine receptor activity
GO:0005044 - scavenger receptor activity
GO:0005654 - nucleoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

141814

CCL5
C-C motif chemokine 5

1

20

Small-scale

0.724

High

141830

CCL8
C-C motif chemokine 8

1

20

Small-scale

0.724

High

141831

CCL7
C-C motif chemokine 7

1

20

Small-scale

0.724

High

141837

CCL14
C-C motif chemokine 14

1

20

Small-scale

0.724

High

141857

CCL13
C-C motif chemokine 13

1

20

Small-scale

0.724

High

141833

CDK18
Cyclin-dependent kinase 18

2

2

High-throughput

0.694

High

141820

NTR1
Neurotensin receptor type 1

1

18

High-throughput

0.691

High

141810

CCL3
C-C motif chemokine 3

1

20

Small-scale

0.618

High

141812

CCL4
C-C motif chemokine 4

1

20

Small-scale

0.618

High

141813

CCL2
C-C motif chemokine 2

1

20

Small-scale

0.618

High

141826

CCL11
Eotaxin

1

20

Small-scale

0.618

High

141823

CXA8
Gap junction alpha-8 protein

2

9

High-throughput

0.606

High

141828

EFNA5
Ephrin-A5

2

3

High-throughput

0.606

High

141834

NIPA4
Magnesium transporter NIPA4

2

2

High-throughput

0.606

High

141877

S13A4
Solute carrier family 13 member 4

2

1

High-throughput

0.606

High

141811

CD20
B-lymphocyte antigen CD20

2

0

High-throughput

0.580

High

141874

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

3

High-throughput

0.553

High

141799

CREB3
Cyclic AMP-responsive element-binding protein 3

1

3

High-throughput

0.541

High

141795

SCAM2
Secretory carrier-associated membrane protein 2

1

5

High-throughput

0.536

High

141796

RER1
Protein RER1

1

4

High-throughput

0.536

High

141797

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.536

High

141798

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

3

High-throughput

0.536

High

141800

S19A2
Thiamine transporter 1

1

3

High-throughput

0.536

High

141801

ATP9A
Probable phospholipid-transporting ATPase IIA

1

10

High-throughput

0.536

High

141802

DGAT1
Diacylglycerol O-acyltransferase 1

1

5

High-throughput

0.536

High

141803

PRAF3
PRA1 family protein 3

1

4

High-throughput

0.536

High

141805

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.536

High

141808

B3A2
Anion exchange protein 2

1

3

High-throughput

0.536

High

141815

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

15

High-throughput

0.536

High

141816

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

16

High-throughput

0.536

High

141817

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

141819

CTR1
High affinity cationic amino acid transporter 1

1

12

High-throughput

0.536

High

141824

AGRE5
Adhesion G protein-coupled receptor E5

1

10

High-throughput

0.536

High

141825

CAV2
Caveolin-2

1

4

High-throughput

0.536

High

141829

AT12A
Potassium-transporting ATPase alpha chain 2

1

16

High-throughput

0.536

High

141832

EFNB1
Ephrin-B1

1

3

High-throughput

0.536

High

141838

YIF1B
Protein YIF1B

1

5

High-throughput

0.536

High

141842

LTMD1
LETM1 domain-containing protein 1

1

1

High-throughput

0.536

High

141846

GOLM1
Golgi membrane protein 1

1

1

High-throughput

0.536

High

141847

TM87A
Transmembrane protein 87A

1

8

High-throughput

0.536

High

141849

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

4

High-throughput

0.536

High

141851

YIPF5
Protein YIPF5

1

3

High-throughput

0.536

High

141853

F241B
Protein FAM241B

1

3

High-throughput

0.536

High

141858

SGMR1
Sigma non-opioid intracellular receptor 1

1

5

High-throughput

0.536

High

141859

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.536

High

141863

YIPF3
Protein YIPF3

1

7

High-throughput

0.536

High

141864

DERL2
Derlin-2

1

3

High-throughput

0.536

High

141865

T126A
Transmembrane protein 126A

1

4

High-throughput

0.536

High

141868

PIGU
GPI-anchor transamidase component PIGU

1

2

High-throughput

0.536

High

141875

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

3

High-throughput

0.536

High

141806

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.513

High

141807

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

141861

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

141878

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.513

High

141809

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

141804

WFS1
Wolframin

1

2

High-throughput

0.489

High

141818

ERD21
ER lumen protein-retaining receptor 1

1

5

High-throughput

0.489

High

141836

PDCD2
Programmed cell death protein 2

1

1

High-throughput

0.489

High

141839

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

13

High-throughput

0.489

High

141840

RABL3
Rab-like protein 3

1

5

High-throughput

0.489

High

141841

TT39A
Tetratricopeptide repeat protein 39A

1

1

High-throughput

0.489

High

141843

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

5

High-throughput

0.489

High

141844

K2013
Uncharacterized protein KIAA2013

1

5

High-throughput

0.489

High

141845

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

3

High-throughput

0.489

High

141848

GOGA5
Golgin subfamily A member 5

1

4

High-throughput

0.489

High

141850

CDS1
Phosphatidate cytidylyltransferase 1

1

3

High-throughput

0.489

High

141852

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

141854

CERS2
Ceramide synthase 2

1

11

High-throughput

0.489

High

141855

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

7

High-throughput

0.489

High

141856

SEC62
Translocation protein SEC62

1

3

High-throughput

0.489

High

141860

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

1

High-throughput

0.489

High

141862

PTSS2
Phosphatidylserine synthase 2

1

7

High-throughput

0.489

High

141866

UN93B
Protein unc-93 homolog B1

1

2

High-throughput

0.489

High

141867

GHITM
Growth hormone-inducible transmembrane protein

1

3

High-throughput

0.489

High

141869

REEP4
Receptor expression-enhancing protein 4

1

2

High-throughput

0.489

High

141870

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.489

High

141871

CERS4
Ceramide synthase 4

1

11

High-throughput

0.489

High

141873

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

High-throughput

0.489

High

141876

ATIF1
ATPase inhibitor, mitochondrial

1

1

High-throughput

0.489

High

141821

SYUA
Alpha-synuclein

1

3

High-throughput

0.481

High

141822

CUX1
Homeobox protein cut-like 1

1

9

High-throughput

0.479

High

141835

CASP
Protein CASP

1

8

High-throughput

0.445

High

141872

KISHB
Protein kish-B

2

0

High-throughput

0.316

High

49416

TM223
Transmembrane protein 223

1

0

High-throughput

0.279

Low

141827

PRELP
Prolargin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025