HitPredict

Interactor 1: AP1B1 (O35643)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18789888
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 943 Mm			1 217
+	Hs
		924449 AP2B1_HUMAN (1-943): 0: 886: 83.88		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		337419 AP2B1_HUMAN (1-943): 0: 886: 83.88		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		69207 AP2B1_HUMAN (1-943): 0: 886: 83.88		A9UF07_HUMAN (4-139): 1.72e-21: 94: 35.46
+	Hs
		1014096 AP1B1_HUMAN (1-943): 0: 900: 96.10		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		1014017 AP1B1_HUMAN (1-943): 0: 900: 96.10		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Hs
		926031 AP2B1_HUMAN (1-943): 0: 886: 83.88		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		925876 AP2B1_HUMAN (1-943): 0: 886: 83.88		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Rn
		923861 AP2B1_RAT (1-943): 0: 886: 83.88		ITSN1_RAT (160-216): 2.86e-10: 61.5: 33.33
+	Hs
		321522 AP2A1_HUMAN (12-941): 0: 628: 17.20		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		302130 AP2A2_HUMAN (12-941): 0: 598: 18.02		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		863196 COPB_HUMAN (6-926): 0: 593: 13.37		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		321464 AP2A1_HUMAN (12-941): 0: 628: 17.20		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		321450 AP2A1_HUMAN (12-941): 0: 628: 17.20		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		69200 AP2A1_HUMAN (12-941): 0: 628: 17.20		A9UF07_HUMAN (4-139): 1.72e-21: 94: 35.46
+	Hs
		321552 AP2A1_HUMAN (12-941): 0: 628: 17.20		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Rn
		88768 D3ZUY8_RAT (12-941): 0: 620: 16.58		ITSN1_RAT (160-216): 2.86e-10: 61.5: 33.33
+	Hs
		302157 AP2A2_HUMAN (12-941): 0: 598: 18.02		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33