HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	16698021
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 1162
+	Mm
		193361 SOCS2_MOUSE (3-221): 1.44e-48: 159: 28.31		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		817309 SOCS6_MOUSE (8-220): 4.11e-43: 153: 23.39		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		817306 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		817307 SOCS7_MOUSE (16-221): 2.42e-38: 141: 25.24		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Hs
		147403 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		LEPR_HUMAN (1-1162): 0: 962: 75.39
+	Hs
		412016 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		PTPRD_HUMAN (41-931): 6.81e-92: 327: 13.98
+	Hs
		411959 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		PTPRF_HUMAN (24-869): 2e-83: 301: 12.06
+	Mm
		56907 FYN_MOUSE (34-177): 1.28e-35: 133: 20.53		PTPRF_MOUSE (24-866): 4.53e-83: 300: 11.85
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		IL6RB_MOUSE (268-883): 1.16e-17: 91.1: 13.57
+	Hs
		147398 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75
+	Hs
		147385 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		147443 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		I12R2_HUMAN (501-819): 9.46e-11: 68.3: 13.86
+	Hs
		147442 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93
+	Hs
		146590 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		560479 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		560471 VAV2_HUMAN (13-205): 3.23e-39: 145: 13.92		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		548653 VAV_HUMAN (4-207): 1.17e-35: 134: 12.75		IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75
+	Hs
		548629 VAV_HUMAN (4-207): 1.17e-35: 134: 12.75		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		1303311 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93
+	Hs
		855816 VAV2_HUMAN (13-205): 3.23e-39: 145: 13.92		TITIN_HUMAN (65-555): 2.05e-09: 64.3: 10.51