HitPredict

Interactor 1: FOXO (O16850)
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)
Gene: daf-16

Interactor 2: SGK1 (Q2PJ68)
Serine/threonine-protein kinase sgk-1 (EC 2.7.11.1) (Serum- and glucocorticoid-inducible kinase homolog) (Serum/glucocorticoid-regulated kinase 1)
Gene: sgk-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 0.60 0.657

The method score is based on:

Property Details
Experiments 18358814, 15068796
Identification Methods enzymatic study, affinity chromatography technology, protein kinase assay, pull down
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002119 - nematode larval development
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0010468 - regulation of gene expression
GO:0035556 - intracellular signal transduction
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 541
Ce

1 463
+ Ce
+ Ce
+ Dm
+ Hs
+ Rn
+ Sp
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Sc

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Last updated: 11Aug2025