Protein: FOXO4
Forkhead box protein O4 (Fork head domain transcription factor AFX1)

Gene: FOXO4
Organism: Homo sapiens
Interactions: 34
UniProt ID: P98177

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003676 - nucleic acid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1023213

CBP
CREB-binding protein

4

20

Small-scale

0.896

High

1023206

REL
Proto-oncogene c-Rel

1

11

High-throughput

0.740

High

1023208

FOXO1
Forkhead box protein O1

1

16

High-throughput

0.691

High

1023205

MDM2
E3 ubiquitin-protein ligase Mdm2

3

4

Small-scale

0.678

High

728171

AKT1
RAC-alpha serine/threonine-protein kinase

3

11

Small-scale

0.664

High

966196

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1023207

1433F
14-3-3 protein eta

3

20

High-throughput

0.662

High

1023204

FOXO4
Forkhead box protein O4

1

15

High-throughput

0.646

High

730510

1433S
14-3-3 protein sigma

2

20

High-throughput

0.631

High

729748

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

764661

CTNB1
Catenin beta-1

2

10

Small-scale

0.584

High

1023214

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

8

Small-scale

0.584

High

71814

FOXO6
Forkhead box protein O6

1

17

High-throughput

0.575

High

172702

XPO1
Exportin-1

1

11

Small-scale

0.561

High

1023210

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.561

High

1023216

NLK
Serine/threonine-protein kinase NLK

1

5

Small-scale

0.561

High

1023215

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

12

Small-scale

0.554

High

407610

S100B
Protein S100-B

1

6

High-throughput

0.536

High

814511

FEN1
Flap endonuclease 1

1

1

High-throughput

0.536

High

990096

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.536

High

1023209

SMAD4
Mothers against decapentaplegic homolog 4

1

19

Small-scale

0.534

High

185614

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

Small-scale

0.515

High

596044

H12
Histone H1.2

1

1

High-throughput

0.515

High

1014473

SMAD3
Mothers against decapentaplegic homolog 3

1

19

Small-scale

0.515

High

395913

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

413625

P53
Cellular tumor antigen p53

1

11

Small-scale

0.501

High

543488

VDR
Vitamin D3 receptor

1

20

Small-scale

0.479

High

593336

PGFRA
Platelet-derived growth factor receptor alpha

1

4

Small-scale

0.479

High

971404

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

1023211

CSN6
COP9 signalosome complex subunit 6

1

4

Small-scale

0.479

High

1023212

COP1
E3 ubiquitin-protein ligase COP1

1

11

Small-scale

0.479

High

926946

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

1023217

FBX7
F-box only protein 7

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025