HitPredict

Interactor 1: PRP4 (O43172)
U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)
Gene: PRPF4

Interactor 2: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0008380 - RNA splicing GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 522 Hs			1 240
+	Hs
		538887 WDR5_HUMAN (2-350): 4.01e-60: 203: 16.19		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Sc
		589078 PRP4_YEAST (323-521): 3.9e-45: 166: 19.02		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Hs
		196951 PRP4_HUMAN (393-522): 8.07e-27: 115: 25.55		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		539186 PRP19_HUMAN (116-478): 4.88e-17: 85.9: 22.49		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		539097 SNR40_HUMAN (441-522): 1.17e-15: 80.4: 28.92		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		927996 SNR40_HUMAN (441-522): 1.17e-15: 80.4: 28.92		RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00
+	Hs
		124015 POC1A_HUMAN (16-221): 2.03e-21: 98.5: 8.25		SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69
+	Hs
		124040 SNR40_HUMAN (441-522): 1.17e-15: 80.4: 28.92		SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69