HitPredict

Interactor 1: SRGP3 (O43295)
SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)
Gene: SRGAP3

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25819436
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1099 Hs			1 352
+	Hs
		200231 SRGP3_HUMAN (1-1099): 0: 799: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		200212 SRGP3_HUMAN (1-1099): 0: 799: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		253384 SRGP2_HUMAN (1-1087): 0: 675: 57.36		SH3R3_HUMAN (270-346): 9.24e-13: 71.3: 35.80
+	Hs
		1148391 RHG17_HUMAN (224-1051): 4.25e-86: 299: 15.45		SHLB1_HUMAN (10-347): 8.42e-72: 229: 24.50
+	Hs
		1052226 RHG17_HUMAN (224-1051): 4.25e-86: 299: 15.45		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		1089302 RHG17_HUMAN (224-1051): 4.25e-86: 299: 15.45		RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35
+	Hs
		1148392 RHG17_HUMAN (224-1051): 4.25e-86: 299: 15.45		3BP1_HUMAN (6-260): 6.66e-38: 145: 17.48
+	Hs
		1089311 RHG44_HUMAN (267-1078): 5.9e-82: 287: 14.95		3BP1_HUMAN (6-260): 6.66e-38: 145: 17.48
+	Hs
		64687 RHG32_HUMAN (311-1098): 9.49e-85: 304: 14.43		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		924636 RHG17_HUMAN (224-1051): 4.25e-86: 299: 15.45		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		993058 RHG01_HUMAN (517-697): 5.31e-18: 90.1: 30.39		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		924608 Q1RLN5_HUMAN (486-694): 7.15e-69: 249: 24.76		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		924686 RHG12_HUMAN (486-694): 3e-68: 248: 24.76		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		1052250 RHG24_HUMAN (520-701): 3.97e-23: 108: 32.09		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		1052327 RHG35_HUMAN (517-668): 1.93e-19: 97.1: 34.42		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		924893 RHG35_HUMAN (517-668): 1.93e-19: 97.1: 34.42		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		1141138 BCR_MOUSE (503-664): 2.26e-17: 90.1: 29.63		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10