HitPredict

Interactor 1: CASL (O35177)
Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
Gene: Nedd9

Interactor 2: SH2D3 (Q9QZS8)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (SH2 domain-containing Eph receptor-binding protein 1)
Gene: Sh2d3c

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20956287
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CAS_C~RasGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 833 Mm			1 854
+	Hs
		1127358 CASL_HUMAN (1-833): 0: 629: 88.61		SH2D3_HUMAN (23-854): 0: 812: 86.40
+	Hs
		294859 CASL_HUMAN (1-833): 0: 629: 88.61		BCAR3_HUMAN (66-854): 0: 666: 39.69
+	Hs
		294847 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		BCAR3_HUMAN (66-854): 0: 666: 39.69
+	Dm
		1270036 Q7KVE5_DROME (6-829): 2.77e-119: 381: 22.88		Q9VMJ4_DROME (67-845): 0: 568: 27.07
+	Dm
		1270027 Q7KVE5_DROME (6-829): 2.77e-119: 381: 22.88		Q8T9B3_DROME (67-845): 0: 567: 27.07
+	Dm
		62641 A4IJ58_DROME (2-829): 8.84e-109: 354: 22.40		Q9VMJ4_DROME (67-845): 0: 568: 27.07
+	Hs
		463518 CASL_HUMAN (1-833): 0: 629: 88.61		LYN_HUMAN (95-443): 2.08e-60: 215: 9.54
+	Mm
		204404 CASL_MOUSE (1-833): 0: 648: 100.00		CRK_MOUSE (203-455): 8.3e-55: 193: 19.78
+	Hs
		440558 CASL_HUMAN (1-833): 0: 629: 88.61		FYN_HUMAN (148-392): 3.36e-58: 210: 11.94
+	Hs
		440075 CASL_HUMAN (1-833): 0: 629: 88.61		LCK_HUMAN (124-572): 1.62e-56: 204: 10.71
+	Hs
		855624 CASL_HUMAN (1-833): 0: 629: 88.61		CRK_HUMAN (203-455): 6.34e-55: 194: 19.78
+	Hs
		855872 CASL_HUMAN (1-833): 0: 629: 88.61		CRKL_HUMAN (214-455): 5.43e-39: 148: 18.96
+	Hs
		557192 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		SRC_HUMAN (77-505): 6.98e-66: 231: 11.79
+	Hs
		463425 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		LYN_HUMAN (95-443): 2.08e-60: 215: 9.54
+	Hs
		440468 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		FYN_HUMAN (148-392): 3.36e-58: 210: 11.94
+	Hs
		473388 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		HCK_HUMAN (65-392): 1.28e-58: 210: 11.05
+	Hs
		463036 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		YES_HUMAN (72-581): 1.3e-57: 208: 10.02
+	Hs
		440009 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		LCK_HUMAN (124-572): 1.62e-56: 204: 10.71
+	Hs
		855567 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		CRK_HUMAN (203-455): 6.34e-55: 194: 19.78
+	Hs
		855840 BCAR1_HUMAN (1-831): 4.49e-95: 319: 32.47		CRKL_HUMAN (214-455): 5.43e-39: 148: 18.96